Guidelines of care for the management of cutaneous squamous cell carcinoma - 28/02/18

Doi : 10.1016/j.jaad.2017.10.007

Work Group
Murad Alam, MD, (Co-Chair) ^a, April Armstrong, MD, MPH ^b, Christian Baum, MD ^c, Jeremy S. Bordeaux, MD, MPH ^d, Marc Brown, MD ^e, Klaus J. Busam, MD ^f, Daniel B. Eisen, MD ^g, Vivek Iyengar, MD ^h, Clifford Lober, MD, JD ⁱ, David J. Margolis, MD, PhD ^j, Jane Messina, MD ^k,^l, Alexander Miller, MD ^m, Stanley Miller, MD ⁿ, Eliot Mostow, MD, MPH ^o, Christen Mowad, MD ^p, Kishwer Nehal, MD ^q, Kristi Schmitt-Burr ^r, Aleksandar Sekulic, MD, PhD ^s, Paul Storrs, MD ^h, Joyce Teng, MD, PhD ^t, Siegrid Yu, MD ^u, Conway Huang, MD ^v, Kevin Boyer, MPH ^w, Wendy Smith Begolka, MBS ^w,^⁎ , Christopher Bichakjian, MD, (Co-Chair) ^x
^a Department of Dermatology, Northwestern University, Chicago, Illinois
^b Department of Dermatology, University of Colorado, Denver, Colorado
^c Department of Dermatology, Mayo Clinic, Rochester, Minnesota
^d Case Western Reserve University School of Medicine, Cleveland, Ohio
^e Department of Dermatology, University of Rochester, Rochester, Minnesota
^f Dermatopathology, Memorial Sloan-Kettering, New York, New York
^q Memorial Sloan-Kettering, New York, New York
^g Department of Dermatology, University of California Davis, Sacramento, California
^h Private practice, Chicago, Illinois
ⁱ Private practice, Kissimmee, Florida
^j University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania
^k Department of Pathology, University of South Florida, Tampa, Florida
^l Department of Pathology, Moffitt Cancer Center, Tampa, Florida
^m Private practice, Yorba Linda, California
ⁿ Private practice, Towson, MD
^o Dermatology Section, NEOMED, Rootstown, Ohio
^p Geisinger Medical Center, Danville, Maryland
^r Basal Cell Carcinoma Nevus Syndrome Life Support Network, Burton, Ohio
^s Mayo Clinic, Phoenix, Arizona
^t Stanford School of Medicine, Stanford, California
^u Dermatologic Surgery and Laser Center, University of California San Francisco, San Francisco, California
^v Department of Dermatology, University of Alabama, Birmingham, Alabama
^w American Academy of Dermatology, Schaumburg, IL
^x Department of Dermatology, University of Michigan, Ann Arbor, Michigan

^∗Correspondence to: Wendy Smith Begolka, MBS, American Academy of Dermatology, 930 East Woodfield Rd, Schaumburg, IL 60173.American Academy of Dermatology930 East Woodfield RdSchaumburgIL60173

Invited Reviewers
John Y.S. Kim, MD ^y, Jeffrey H. Kozlow, MD, MS ^z, Bharat Mittal, MD ^aa, Jeffrey Moyer, MD ^bb, Thomas Olenecki, DO ^cc, Phillip Rodgers, MD ^dd
^y Department of Plastic and Reconstructive Surgery, Northwestern University, Chicago, Illinois
^aa Department of Radiation Oncology, Northwestern University, Chicago, Illinois
^z Section of Plastic and Reconstructive Surgery, University of Michigan, Ann Arbor, Michigan
^bb Department of Otolaryngology, Plastic/Head/Neck Surgery, University of Michigan, Ann Arbor, Michigan
^dd Department of Family Medicine, University of Michigan, Ann Arbor, Michigan
^cc Department of Internal Medicine, Ohio State University, Columbus, Ohio

Abstract

Cutaneous squamous cell carcinoma (cSCC) is the second most common form of human cancer and has an increasing annual incidence. Although most cSCC is cured with office-based therapy, advanced cSCC poses a significant risk for morbidity, impact on quality of life, and death. This document provides evidence-based recommendations for the management of patients with cSCC. Topics addressed include biopsy techniques and histopathologic assessment, tumor staging, surgical and nonsurgical management, follow-up and prevention of recurrence, and management of advanced disease. The primary focus of these recommendations is on evaluation and management of primary cSCC and localized disease, but where relevant, applicability to recurrent cSCC is noted, as is general information on the management of patients with metastatic disease.

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Key words : biopsy, curettage, metastasis, phototherapy, radiotherapy, squamous cell carcinoma, staging, surgery, surveillance, topical therapy

Abbreviations used : AAD, AJCC, BCC, BWH, C&E, CT, 5-FU, MM, MMS, NCCN, PI, RCT, cSCC, SLNB, SOTR

Plan

	Funding sources: None.
	The management of conflict of interests for this guideline series complies with the Council of Medical Special Societies' Code of Interactions with Companies. The authors' conflict of interest/disclosure statements appear at the end of this article.
	Reprint requests: guidelines@aad.org.

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Vol 78 - N° 3

P. 560-578 - mars 2018 Retour au numéro

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Guidelines of care for the management of cutaneous squamous cell carcinoma - 28/02/18

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