Article

Access to the text (HTML) Access to the text (HTML)
PDF Access to the PDF text
Advertising


Access to the full text of this article requires a subscription.
  • If you are a subscriber, please sign in 'My Account' at the top right of the screen.

  • If you want to subscribe to this journal, see our rates

  • You can purchase this item in Pay Per ViewPay per View - FAQ : 30,00 € Taxes included to order
    Pages Iconography Videos Other
    5 0 0 0


Archives de pédiatrie
Volume 25, n° 3
pages 177-181 (avril 2018)
Doi : 10.1016/j.arcped.2018.01.008
Received : 27 June 2016 ;  accepted : 28 January 2018
Research Papers

CD36 gene polymorphism and plasma sCD36 as the risk factor in higher cholesterolemia
 

M.E. Rać a, , K. Safranow a, B. Garanty-Bogacka b, V. Dziedziejko a, G. Kurzawski c, M. Goschorska a, A. Kuligowska a, N. Pauli a, D. Chlubek a
a Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Powstańców Wielkopolskich 72, 70–111 Szczecin, Poland 
b Independent Laboratory of Propedeutics in Pediatrics, Pomeranian Medical University, Unii Lubelskiej 1, 71–252 Szczecin, Poland 
c Department of Genetics and Pathomorphology, Pomeranian Medical University, Powstańców Wielkopolskich 72, 70–111 Szczecin, Poland 

Corresponding author.
Abstract
Introduction

The receptor CD36 has been reported to play an important role in atherogenicity. The aim of this study was to gain insight into the relationship between CD36 gene polymorphisms or the plasma concentration of sCD36 and clinical or biochemical parameters in children.

Patients and methods

The study groups comprised Caucasian children with and without hypercholesterolemia. The alterations in the CD36 gene were detected by DHPLC and the plasma concentrations of sCD36 were measured by ELISA.

Results

The data presented suggest that the IVS4-10A allele of CD36 (rs3211892) is associated with a lower risk of hypercholesterolemia. We observed a negative correlation of the sCD36 concentration with uric acid and insulin concentrations, the HOMA-IR ratio, weight, waist and hip circumference, systolic blood pressure, body mass index, waist–hip ratio and mean arterial pressure ratio, but a positive correlation with HDL cholesterol and ApoA1 concentrations. Female gender was a significant independent predictor of a higher plasma sCD36 concentration.

Conclusions

The data presented suggest a possible protective effect of a higher sCD36 concentration in relation to metabolic syndrome components.

The full text of this article is available in PDF format.

Keywords : CD36 gene, Plasma sCD36, Children, Hypercholesterolemia, Cardiovascular risk factor




© 2018  Elsevier Masson SAS. All Rights Reserved.
EM-CONSULTE.COM is registrered at the CNIL, déclaration n° 1286925.
As per the Law relating to information storage and personal integrity, you have the right to oppose (art 26 of that law), access (art 34 of that law) and rectify (art 36 of that law) your personal data. You may thus request that your data, should it be inaccurate, incomplete, unclear, outdated, not be used or stored, be corrected, clarified, updated or deleted.
Personal information regarding our website's visitors, including their identity, is confidential.
The owners of this website hereby guarantee to respect the legal confidentiality conditions, applicable in France, and not to disclose this data to third parties.
Close
Article Outline