The association between dermoscopic features and BRAF mutational status in cutaneous melanoma: Significance of the blue-white veil - 19/04/18
, Eduardo Nagore, MD, PhD c, d, Zaida García-Casado, PhD e, Rafael Botella-Estrada, MD, PhD f, gAbstract |
Background |
The genetic basis of melanoma affects its clinicopathologic characteristics and increasingly influences its management. B-Raf proto-oncogene, serine/threonine kinase gene (BRAF)-mutated melanoma may present with specific dermoscopic features.
Objectives |
To identify the dermoscopic features associated with BRAF mutation in cutaneous melanoma and to evaluate a model capable of predicting BRAF mutations on the basis of dermoscopic and clinicopathologic features that are easily accessible in normal clinical practice.
Methods |
A prospective, cross-sectional, observational, and descriptive study was performed. A total of 93 cutaneous melanomas with dermoscopic images from 93 patients were included. BRAF mutational status was determined by genetic analysis using 2 methods: cobas 4800 BRAF V600 Mutation Test (Roche Molecular Systems, Pleasanton, CA) and Sanger sequencing. Clinicopathologic data were collected; dermoscopic images were analyzed by 2 independent blind observers.
Results |
Blue-white veil in dermoscopy was significantly associated with BRAF mutations (odds ratio, 4.3; 95% confidence interval, 1.6-11.5; P = .003). Patients with BRAF-mutated melanomas were significantly younger than those with wild-type melanomas (odds ratio, 0.96; 95% confidence interval, 0.93-0.99; P = .008). On the basis of these 2 variables, it was possible to predict BRAF mutational status in melanoma with 73% accuracy.
Limitations |
Histologic data were obtained from pathology reports. The accuracy of the predictive model has not been tested with a new data set.
Conclusions |
Blue-white veil in dermoscopy is associated with BRAF mutations in cutaneous melanoma.
Le texte complet de cet article est disponible en PDF.Key words : blue-white veil, BRAF, dermatology, dermoscopy, exophytic papillary structures, genetics, melanoma, oncology, pathology, ulceration, streaks
Plan
| Funding sources: None. |
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| Conflicts of interest: None disclosed. |
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| Reprints not available from the authors. |
Vol 78 - N° 5
P. 920 - mai 2018 Retour au numéro
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