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Joint Bone Spine
Volume 85, n° 6
pages 727-731 (décembre 2018)
Doi : 10.1016/j.jbspin.2018.02.006
accepted : 9 February 2018
Original Articles

Evaluation of bone quality with trabecular bone score in active spondyloarthritis
 

Karima Boussoualim a, Adamah Amouzougan a, Beatrice Pallot-Prades a, Delphine Denarié a, Philippe Collet a, Hubert Marotte a, Thierry Thomas a, b, c,
a Rheumatology Department, CHU de St-Etienne, 42055 Saint-Etienne cedex 2, France 
b INSERM U1059, Laboratoire de Biologie Intégrée du Tissu Osseux, 42055 Saint-Etienne cedex 2, France 
c Rheumatology Department, Université de Lyon, University Hospital of Saint-Etienne, 42055 Saint-Etienne cedex 2, France 

Corresponding author at: Rheumatology Department, CHU de St-Etienne, 42055 Saint-Etienne cedex 2, France.Rheumatology Department, CHU de St-EtienneSaint-Etienne cedex 242055France
Abstract
Objective

Many patients with spondyloarthritis (SpA) are at risk of fracture due to bone fragility, whereas their bone mineral density (BMD) is not significantly diminished. Other tools, such as trabecular bone score (TBS), evaluating other characteristics of bone tissue are therefore necessary in order to evaluate bone changes in these patients. Therefore we evaluated TBS as a bone quality marker, in a cohort of patients with SpA and investigated which clinical and biological factors were correlated with TBS values.

Methods

Patients fulfilling ASAS criteria of SpA with a BMD assessment and visiting our department for initiation or switch of a biologic treatment were selected. The clinical and biological data were collected at the time of BMD measurement.

Results

Ninety-five patients were included in the study, with a mean age of 40.2 and a mean disease duration of 8.2 years. Lumbar BMD T -score was <−1 and <−2.5 in 17% and 3% of patients, respectively. On average, TBS value was 1.34±0.12. Lumbar BMD was positively correlated with TBS (r =0.61), while disease duration, disease activity score and serum PTH levels were negatively correlated with TBS (r =−0.24, r =−0.33, and r =−0.27, respectively). These correlations persisted in a multivariate analysis. Furthermore, more than half of the patients with a BMD level above −2.5 T -score had a low TBS value.

Conclusion

Our results show that TBS provides information additional to BMD on the bone status of patients with SpA. They suggest that TBS may help in identifying those patients at risk of fracture.

The full text of this article is available in PDF format.

Keywords : Spondyloarthritis, Osteoporosis, Trabecular bone score




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