Basal cell carcinoma : Epidemiology; pathophysiology; clinical and histological subtypes; and disease associations - 14/01/19

Doi : 10.1016/j.jaad.2018.03.060

Michael C. Cameron, MD ^a, Erica Lee, MD ^a, Brian P. Hibler, MD ^a, Christopher A. Barker, MD ^b, Shoko Mori, BS ^a, Miguel Cordova, MD ^a, Kishwer S. Nehal, MD ^a, Anthony M. Rossi, MD ^a,^⁎
^a Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York
^b Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York

^∗Address correspondence to: Anthony M. Rossi, MD, Division of Dermatology, Memorial Sloan Kettering Cancer Center, 16 E 60th St, 4th Floor, New York, NY 10022.Division of DermatologyMemorial Sloan Kettering Cancer Center16 E 60th St, 4th FloorNew YorkNY10022

Abstract

As the most common human cancer worldwide and continuing to increase in incidence, basal cell carcinoma is associated with significant morbidity and cost. Continued advances in research have refined both our insight and approach to this seemingly ubiquitous disease. This 2-part continuing medical education article will provide a comprehensive and contemporary review of basal cell carcinoma. The first article in this series describes our current understanding of this disease regarding epidemiology, cost, clinical and histopathologic presentations, carcinogenesis, natural history, and disease associations.

Le texte complet de cet article est disponible en PDF.

Key words : associations, basal cell carcinoma, BCC, cost, epidemiology, genetics, keratinocyte carcinoma, natural history, nonmelanoma skin cancer, skin cancer

Abbreviations used : BCC, Hh, KC, NBCC, PNI, SCC, Shh, UV

Plan

Epidemiology and cost

Clinical presentation and associated histologic findings

Carcinogenesis and natural history

Environmental, disease, and treatment associations

	Supported by National Institutes of Health/National Cancer Institute Cancer Center support grant P30 CA008748.
	Conflicts of interest: None disclosed.
	Date of release: February 2019
	Expiration date: February 2022