Prestin autoantibodies screening in idiopathic sudden sensorineural hearing loss - 13/03/19
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Abstract |
Objectives |
To define the clinical association of serum prestin autoantibodies and their impact on prognosis, as specific serum diagnostic markers in patients with idiopathic sudden sensorineural hearing loss (ISSNHL).
Design |
Sera from 63 patients with ISSNHL were screened prospectively for the presence of prestin autoantibodies by an enzyme-linked immunosorbent assay (Elisa) test. Serum was assayed for anti-prestin IgG antibodies using recombinant human prestin (SLC26 A5). Demographic, clinical, and audiometric variables were analyzed.
Results |
Two patients (3.17%) had demonstrable anti-prestin antibodies in serum (exact 95% CI: −1.16% to 7.5%). No statistically significant association was found between prestin autoantibodies and demographic or audiologic parameters.
Conclusions |
This preliminary and novel study does not support the presence of an active humoral immune reaction against prestin in ISSNHL.
Le texte complet de cet article est disponible en PDF.Keywords : Sudden sensorineural hearing loss, Prestin, Anti-prestin, Autoantibodies, Elisa
Plan
Vol 136 - N° 2
P. 99-101 - avril 2019 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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