Type 1 innate lymphoid cells are associated with type 2 diabetes - 27/03/19

Doi : 10.1016/j.diabet.2018.08.005

F. Liu ^a,^{^{1
Fangcen Liu, Hongdong Wang and Wenhuan Feng contributed equally to this manuscript.}}, H. Wang ^b,^{^{1
Fangcen Liu, Hongdong Wang and Wenhuan Feng contributed equally to this manuscript.}}, W. Feng ^b,^{^{1
Fangcen Liu, Hongdong Wang and Wenhuan Feng contributed equally to this manuscript.}}, X. Ye ^b, X. Sun ^c, C. Jiang ^c, X. Chu ^c, P. Zhang ^b, C. Jiang ^b, Y. Wang ^b, D. Zhu ^a,^b,^⁎ , Y. Bi ^b
^a Department of Endocrinology, Drum Tower Clinical College of Nanjing Medical University, Nanjing, China
^b Department of Endocrinology, Drum Tower Hospital affiliated to Nanjing University Medical School, Nanjing, China
^c Department of General Surgery, Drum Tower Hospital affiliated to Nanjing University Medical School, Nanjing, China

^⁎Corresponding author at: Drum Tower Hospital affiliated to Nanjing University Medical School, Department of Endocrinology, No. 321 Zhongshan Road, 210093 Nanjing, Jiangsu, PR China.Drum Tower Hospital affiliated to Nanjing University Medical SchoolDepartment of EndocrinologyNo. 321 Zhongshan RoadNanjingJiangsu210093PR China

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Abstract

Aim

Type 1 innate lymphoid cells (ILC1s) play a major role in regulating systemic inflammatory diseases. However, the relationship between ILC1s and type 2 diabetes (T2D) remains unclear. Thus, the present study investigated the relationship between ILC1s and glucose homoeostasis in humans.

Methods

A total of 37 newly diagnosed T2D patients and 32 subjects with normal glucose tolerance (NGT), matched for age and body mass index (BMI), were enrolled in the study. Flow cytometric analysis of ILC1s derived from peripheral blood mononuclear cells (PBMCs) and omental adipose tissue was performed.

Results

T2D patients displayed greater numbers and frequencies of circulating and adipose tissue ILC1s (P < 0.05) compared with NGT subjects, and the two types of ILC1s correlated positively with each other. Circulating ILC1s were positively associated with glycated haemoglobin (HbA_1c), fasting plasma glucose (FPG), homoeostasis model assessment for insulin resistance (HOMA-IR), adipose tissue insulin resistance index (Adipo-IR) and serum free fatty acids (FFAs). A logistic regression model revealed that patients with higher ILC1 levels exhibited a 13.481-fold greater risk of developing T2D.

Conclusion

This study is the first to provide evidence that ILC1 abnormalities are involved in the development of diabetes. The data also suggest a potential role of ILC1s as therapeutic indicators in the treatment of T2D.

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Abbreviations : ILC1s, T2D, NGT, BMI, PBMCs, SVF, HbA1c, FPG, HOMA-IR, Adipo-IR, FFA, OGTT, WHR, ALT, AST, GGT, eGFR, CKD-Epi, CBC, TGs, TC, HDL-C, LDL-C, HOMA-β, CPTs, PBS, FBS, RBC, HFD, WT, OR, CI, NK, Eomes