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Journal of Stomatology Oral and Maxillofacial Surgery
Volume 120, n° 2
pages 116-121 (avril 2019)
Doi : 10.1016/j.jormas.2018.10.001
Received : 25 May 2018 ;  accepted : 14 October 2018
Original Articles

Scapula pre-augmentation in sheep with polycaprolactone tricalcium phosphate scaffolds
 

S. Spalthoff , R. Zimmerer, J. Dittmann, P. Korn, N.-C. Gellrich, P. Jehn
 Department of Oral and Maxillofacial Surgery, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany 

Corresponding author.
Abstract

A scapula free flap is a commonly used method to reconstruct intraoral defects of the mandible and maxilla. Despite its clear advantages, it shows some deficiencies concerning the amount and shape of the available bone, especially with respect to later implant placement. To overcome these limitations, we pre-augmented the scapula prior to a potential flap-raising procedure with polycaprolactone (PCL) tricalcium phosphate (TCP) scaffolds in a sheep model. In our study, the scapula angle was augmented with a block of PCL-TCP in three adult sheep. After 6 months, the amount of newly formed bone and scaffold degradation were evaluated using cone-beam computed tomography scans and histomorphometric analysis. All animals survived the study and showed no problems in the augmented regions. The scaffolds were attached firmly to the scapula and showed a bonelike consistency. A fair amount of the scaffold material was degraded and replaced by vital bone. Our method seems to be a valid approach to pre-augment the scapula in sheep. In further experiments, it will be interesting to determine whether it is possible to transplant a modified scapula flap to an intraoral defect site.

The full text of this article is available in PDF format.

Keywords : Pre-augmentation, PCL-TCP, Scapula flap, Tissue engineering




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