Article

Access to the text (HTML) Access to the text (HTML)
PDF Access to the PDF text
Advertising


Access to the full text of this article requires a subscription.
  • If you are a subscriber, please sign in 'My Account' at the top right of the screen.

  • If you want to subscribe to this journal, see our rates

  • You can purchase this item in Pay Per ViewPay per View - FAQ : 30,00 € Taxes included to order
    Pages Iconography Videos Other
    5 0 0 0


Archives de pédiatrie
Volume 26, n° 3
pages 133-137 (avril 2019)
Doi : 10.1016/j.arcped.2019.02.010
Received : 3 April 2018 ;  accepted : 9 February 2019
Research Papers

Lyme neuroborreliosis in children: Report of nine cases and a review of the literature
 

H. Guet-Revillet a, , C. Levy b, c, d, e, C. Vallet f, V. Maghraoui-Slim g, M.-A. Dommergues b, h, V. Hentgen h, C. Paget i, V. Laugel j, R. Cohen b, c, d, e, A. Ferroni a
a Service de microbiologie, hôpital Necker-enfants-malades, Assistance publique–hôpitaux de Paris, 149, rue de Sèvres, 75015 Paris, France 
b Groupe de pathologie infectieuse pédiatrique (GPIP), CHU de Lenval, hôpitaux pédiatriques, 57, avenue de la Californie, 06200 Nice, France 
c Association clinique et thérapeutique infantile du Val-de-Marne (ACTIV), 27, rue d’Inkermann, 94100 Saint-Maur-des-Fossés, France 
d Centre de recherche clinique, centre hospitalier intercommunal de Créteil, 40, avenue de Verdun, 94010 Créteil cedex, France 
e UMR 955, GRC, groupe d’étude des maladies infectieuses néonatales et infantiles (GEMINI), université Paris Est, IMRB Institut Mondor de recherche biomédicale, 94000 Créteil, France 
f Service de pédiatrie, centre hospitalier Compiègne-Noyon, 8, avenue Henri-Adnot, ZAC de Mercières 3, 60200 Compiègne, France 
g Unité policlinique pédiatrique, hôpital Bicêtre, 8, rue du Général Leclerc, 94270 Le Kremlin-Bicêtre, France 
h Service de pédiatrie, centre hospitalier de Versailles, 177, rue de Versailles, 78150 Le Chesnay, France 
i Service de pédiatrie, centre hospitalier de Chambéry, place Lucien-Biset, 73011 Chambéry, France 
j Service de pédiatrie 1, hôpital de Hautepierre, 1, avenue Molière, 67200 Strasbourg, France 

Corresponding author. TSA 40031, laboratoire de bactériologie-hygiène, Institut Fédératif de Biologie, hôpital Purpan, 31059 Toulouse cedex 9, France.TSA 40031, laboratoire de bactériologie-hygiène, Institut Fédératif de Biologie, hôpital PurpanToulouse cedex 931059France
Abstract

Lyme neuroborreliosis is a bacterial infection caused by the dissemination and proliferation of a Borrelia species in the central nervous system. Neuroborreliosis occurs after transmission of the pathogen from an infected tick to a human host during a tick bite. We report nine cases of pediatric neuroborreliosis collected by the National Observatory of Pediatric Bacterial Meningitis in France between 2001 and 2012. The nine children, aged 4–13 years, were identified in northern and eastern France and had the following clinical features: meningeal irritation alone or with facial palsy, or isolated facial palsy. All cases showed anti-Borrelia antibodies in cerebrospinal fluid or serum, or with a positive Borrelia PCR in the CSF. The outcome was favorable in all cases after a 2- to 3-week course of third-generation cephalosporin. On the basis of these nine pediatric cases, this study provides an update on the epidemiology, pathophysiology, diagnostic strategy, and treatment of neuroborreliosis, with insight into the specific features of pediatric neuroborreliosis and the difficulties encountered in the diagnosis of this infection.

The full text of this article is available in PDF format.

Keywords : Borrelia , Neuroborreliosis, Lyme disease, Meningitis, Children




© 2019  Elsevier Masson SAS. All Rights Reserved.
EM-CONSULTE.COM is registrered at the CNIL, déclaration n° 1286925.
As per the Law relating to information storage and personal integrity, you have the right to oppose (art 26 of that law), access (art 34 of that law) and rectify (art 36 of that law) your personal data. You may thus request that your data, should it be inaccurate, incomplete, unclear, outdated, not be used or stored, be corrected, clarified, updated or deleted.
Personal information regarding our website's visitors, including their identity, is confidential.
The owners of this website hereby guarantee to respect the legal confidentiality conditions, applicable in France, and not to disclose this data to third parties.
Close
Article Outline