Acquired disorders with depigmentation: A systematic approach to vitiliginoid conditions - 12/04/19

Doi : 10.1016/j.jaad.2018.03.063

Mohammed D. Saleem, MD, MPH ^a,^⁎ , Elias Oussedik, MD ^b, Jennifer J. Schoch, MD ^c, Adam C. Berger, MD ^d, Mauro Picardo, MD, PhD ^e
^a Department of Internal Medicine, University of Florida College of Medicine and University of Florida Health, Gainesville, Florida
^b McGill University, Montreal, Quebec, Canada
^c Department of Dermatology and Pediatrics, University of Florida, Gainesville, Florida
^d Department of Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania
^e Department of Dermatology and Pediatric Dermatology, Cutaneous Physiopathology and Integrated Center of Metabolomics Research, San Gallicano Dermatologic Institute, IRCCS, Rome, Italy

^∗Correspondence to: Mohammed D. Saleem, MD, MPH, University of Florida College of Medicine, PO Box 100277, Gainesville, FL 32610-0277.University of Florida College of MedicinePO Box 100277GainesvilleFL32610-0277

Abstract

Acquired disorders with depigmentation are commonly encountered by dermatologists and present with a wide differential diagnosis. Vitiligo, the most common disorder of acquired depigmentation, is characterized by well-defined depigmented macules and patches. Other conditions, such as chemical leukoderma, can present with similar findings, and are often easily mistaken for vitiligo. Key clinical features can help differentiate between acquired disorders of depigmentation. The first article in this continuing medical education series focuses on conditions with a vitiligo-like phenotype. Early recognition and adequate treatment of these conditions is critical in providing appropriate prognostication and treatment.

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Key words : Alezzandrini syndrome, chemical leukoderma, extramammary Paget disease, halo nevi, lichen sclerosus, melanoma-associated leukoderma, onchocerciasis, pinta, scleroderma leukoderma, Vogt-Koyanagi-Harada

Plan

Vitiliginoid disorders

Generalized depigmentation

Chemical leukoderma

Melanoma-associated leukoderma

Vogt-Koyanagi-Harada disease and Alezzandrini syndrome

Scleroderma leukoderma

Tropical diseases

Localized depigmentation

Postinflammatory depigmentation

Spontaneous neoplastic regression

Other considerations

	Funding sources: None.
	Conflicts of interest: None disclosed.
	Reprints not available from the authors.
	Date of release: May 2019
	Expiration date: May 2022