1 Iconography
Access to the text (HTML) Access to the text (HTML)
PDF Access to the PDF text

Access to the full text of this article requires a subscription.
  • If you are a subscriber, please sign in 'My Account' at the top right of the screen.

  • If you want to subscribe to this journal, see our rates

Anaesthesia Critical Care & Pain Medicine
Sous presse. Epreuves corrigées par l'auteur. Disponible en ligne depuis le jeudi 25 avril 2019
Doi : 10.1016/j.accpm.2019.04.002
Thiopental versus propofol on the outcome of the newborn after caesarean section: An impact study

Olivier Montandrau a, , Fabien Espitalier a , Joseph Bouyou b , Marc Laffon a , Francis Remérand a
a Department of anaesthesia and intensive care, Hôpital Trousseau, CHRU de Tours, 37044 cedex 9 Tours, France 
b Department of obstetrics and gynaecology, Hôpital Lariboisière AP–HP, 2, rue Ambroise Paré, 75010 Paris, France 

Corresponding author.

In 2011, the company that produced thiopental in France and in the United States stopped its marketing. Because of limited evidences, the choice of the best induction agent for caesarean section remains controversial, especially in emergency. The objective of this study was to compare the effects of propofol versus thiopental on the Apgar score of the newborn.


Newborns delivered by elective or emergency caesarean section under general anaesthesia in a university hospital were included from January 2009 to December 2013. Two periods, according to the hypnotic drug used, were compared in this before-and-after comparative study: thiopental before May 2011 and propofol after. The primary outcome was to compare the proportion of newborns with a 5-minute Apgar Score < 7 between both groups.


367 newborns were enrolled, 178 in thiopental group and 189 in propofol group . Demographic and clinical characteristics were similar in both groups. The occurrence of a 5-minute Apgar Score less than 7 was not influenced by the use of propofol (OR 1.40 [CI 95% 0.90–2.20] P  = 0.135). Blood gas analyses and admission's rate in neonatal intensive care unit were similar in both groups.


Thiopental and propofol do not appear to present significant difference in term of outcome of the newborn after caesarean section. In this situation, propofol may probably be a reliable alternative to the supply reduction of thiopental imposed by forces. Prospective studies are required to confirm the safety of propofol, particularly in the long term.

The full text of this article is available in PDF format.

Keywords : Anaesthetics i.v., Propofol, Anaesthetics i.v., Thiopental, Apgar score, Caesarean section, General anaesthesia

© 2019  Société française d'anesthésie et de réanimation (Sfar)@@#104156@@
EM-CONSULTE.COM is registrered at the CNIL, déclaration n° 1286925.
As per the Law relating to information storage and personal integrity, you have the right to oppose (art 26 of that law), access (art 34 of that law) and rectify (art 36 of that law) your personal data. You may thus request that your data, should it be inaccurate, incomplete, unclear, outdated, not be used or stored, be corrected, clarified, updated or deleted.
Personal information regarding our website's visitors, including their identity, is confidential.
The owners of this website hereby guarantee to respect the legal confidentiality conditions, applicable in France, and not to disclose this data to third parties.
Article Outline