Article

1 Iconography
Access to the text (HTML) Access to the text (HTML)
PDF Access to the PDF text
Advertising


Access to the full text of this article requires a subscription.
  • If you are a subscriber, please sign in 'My Account' at the top right of the screen.

  • If you want to subscribe to this journal, see our rates



Journal of the American Academy of Dermatology
Volume 80, n° 6
pages 1746-1752 (juin 2019)
Doi : 10.1016/j.jaad.2018.12.031
accepted : 17 December 2018
Reviews

The uses of naltrexone in dermatologic conditions
 

Brigette Lee, BS a, , Dirk M. Elston, MD b
a Baylor College of Medicine, Houston, Texas 
b Medical University of South Carolina, Charleston, South Carolina 

Reprint requests: Brigette Lee, BS, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030.Baylor College of Medicine1 Baylor PlazaHoustonTX77030
Abstract
Background

Naltrexone in standard and reduced doses is efficacious in many inflammatory and acantholytic disorders.

Objective

We summarized the current data of naltrexone that are relevant to dermatologic practice.

Methods

An English language PubMed literature search was performed using the terms naltrexone, low-dose naltrexone, Hailey–Hailey, psoriasis, lichen planopilaris, alopecia, opioid, opioid receptor, treatment, dermatology, monitoring, side effect, skin, pruritus, cutaneous, acantholytic, and Darier.

Results

Opioid receptors are found throughout the skin and affect cell proliferation, migration, and adhesion. μ Opioid receptors have been found in all layers of the epidermis, while δ receptors are concentrated at cell junctions and can reduce desmoglein expression. Typical doses of naltrexone result in continuous binding to receptors. Low doses result in intermittent blockade with increased ligand and receptor expression, potentiating their effect.

Limitations

Our review was restricted to the English language literature.

Conclusion

Naltrexone affects inflammation, cell adhesion, and keratinocyte proliferation and migration. While low-dose naltrexone has demonstrated efficacy in treating patients with Hailey–Hailey disease, further dose-ranging studies are needed. Data suggest that naltrexone could be helpful in the treatment of pruritus and a variety of inflammatory and acantholytic skin diseases that are refractory to other treatments. At higher doses, liver function tests should be monitored on a periodic basis.

The full text of this article is available in PDF format.

Key words : dermatology, Hailey–Hailey disease, lichen planopilaris, low-dose naltrexone, naltrexone, opioid receptor, opioid receptor antagonist, opioids, pruritus, psoriasis, scleroderma

Abbreviations used : LDN, OGF, OGFr



 Funding sources: None.
 Conflicts of interest: None disclosed.



© 2018  American Academy of Dermatology, Inc.@@#104156@@
EM-CONSULTE.COM is registrered at the CNIL, déclaration n° 1286925.
As per the Law relating to information storage and personal integrity, you have the right to oppose (art 26 of that law), access (art 34 of that law) and rectify (art 36 of that law) your personal data. You may thus request that your data, should it be inaccurate, incomplete, unclear, outdated, not be used or stored, be corrected, clarified, updated or deleted.
Personal information regarding our website's visitors, including their identity, is confidential.
The owners of this website hereby guarantee to respect the legal confidentiality conditions, applicable in France, and not to disclose this data to third parties.
Close
Article Outline