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Gastroentérologie Clinique et Biologique
Vol 31, N° 3  - mars 2007
pp. 325-332
Doi : GCB-03-2007-31-3-0399-8320-101019-200520016
Le traitement de l'hépatite B : stratégies actuelles
Treatment of hepatitis B. Current strategies
 
Figure 1

Traitements anti-VHB disponibles, antiviraux et immunomodulateurs (le caractère immunomédié de la physiopathologie de l'infection justifie la combinaison d'approches antivirales et immunostimulantes dont l'interféron est un exemple).
Available anti-HBV therapies, including antivirals and immunomodulatory drugs (the immune-mediated mechanisms of HBV pathobiology evidence the relevance of combination of antiviral and immunomodulatory strategies which interferon is an example).
Figure 2

Les 3 phases de l'histoire naturelle de l'infection virale B selon la charge virale : seule la phase d'immunoélimination (impact histologique hépatique –A>1 et/ou F>1- lié à une multiplication virale significative) justifie un traitement.
The 3 phases of the natural history of HBV infection according to the viral load: the phase of immune elimination (which results in a significant histopathological impact –activity A>1 and/or fibrosis F>1- associated with a significant viral replication) only requires a treatment.
Figure 3

Exemples de virosuppression (décroissance de la charge virale B) selon les traitements antiviraux actuellement disponibles.
Examples of viral suppression (decline of serum HBV DNA) according to available antiviral treatments.
Figure 4

Exemple d'algorithme de traitement de l'hépatite chronique B.Les analogues sont le plus souvent utilsés en première ligne.
Example of algorithm of treatments of HBV infection. Analogues are usually used as first line treatment.
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