Incidence of bloodstream infections and predictive value of qualitative and quantitative skin cultures of patients with overlap syndrome or toxic epidermal necrolysis: A retrospective observational cohort study of 98 cases - 27/07/19
Abstract |
Background |
Epidermal necrolysis (EN) involving ≥10% of the body surface area (BSA) is often complicated by bacterial infections.
Objective |
We sought to describe the epidemiology of bloodstream infections (BSIs) in EN involving a BSA ≥10% and the diagnostic performances of skin cultures for predicting the pathogen(s) isolated from BSIs.
Methods |
This retrospective single-center observational study was conducted between 2009 and 2017. All patients referred at the acute phase for EN involving a BSA ≥10% were included. All clinical and bacteriologically relevant data were collected (blood and skin cultures results, number, and severity and time of BSI). Sensitivity, specificity, and predictive values of skin cultures and impact of the bacterial inoculum were investigated.
Results |
Of 98 patients, 46 (46.9%) had ≥1 BSI episode during the hospital stay (BSIs were caused by Staphylococcus aureus [n = 17, 36.9%] and Pseudomonas aeruginosa [n = 17, 36.9%]). Skin cultures were concordant with blood cultures in 32 cases (71.1%). The positive and negative predictive values were 57.7% and 89.4% for S aureus and 50.0% and 80.9% for P aeruginosa, respectively. BSI increased with cutaneous inoculum of S aureus.
Limitations |
This was a retrospective single-center design with a low total number of BSIs.
Conclusion |
Skin cultures for S aureus and P aeruginosa may help predict the pathogens involved in BSIs.
Le texte complet de cet article est disponible en PDF.Key words : blood culture, bloodstream infection, epidermal necrolysis, Lyell syndrome, SJS-TEN overlap syndrome, skin culture
Abbreviations used : BSI, BSA, CFU, EN, SJS, TEN
Plan
| Drs de Prost and Ingen-Housz-Oro contributed equally to this article. |
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| Funding sources: None. |
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| Conflicts of interest: None disclosed. |
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| Presented at the Journées Dermatologiques de Paris, Paris, France, December 11-15, 2018. |
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| Reprints are not available from the authors. |
Vol 81 - N° 2
P. 342-347 - août 2019 Retour au numéro
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