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Journal of the American Academy of Dermatology
Sous presse. Epreuves corrigées par l'auteur. Disponible en ligne depuis le vendredi 23 août 2019
Doi : 10.1016/j.jaad.2019.07.036
accepted : 11 July 2019
Comorbid diseases of vitiligo: A 10-year cross-sectional retrospective study of an urban US population

Ali Hadi, MD a, Jason F. Wang, BA b, Pushpinder Uppal, MD c, Lauren A. Penn, MD d, Nada Elbuluk, MD, MSc e,
a Kimberly and Eric J. Waldman Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York 
b The Ronald O. Perelman Department of Dermatology, New York University, New York, New York 
c Department of Anesthesiology, University of Maryland School of Medicine, Baltimore, Maryland 
d Westmed Medical Group, Purchase, New York 
e Department of Dermatology, Keck School of Medicine of University of Southern California, Los Angeles, California 

Reprint requests: Nada Elbuluk, MD, MSc, 1450 San Pablo St, Ste 2000, Los Angeles, CA 90033.1450 San Pablo StSte 2000Los AngelesCA90033

Vitiligo is associated with medical conditions, primarily autoimmune disorders; however, only a few studies in the United States have investigated these associations.


Our purpose was to investigate the diseases associated with vitiligo in the New York, New York, population and evaluate if these associations differ by race/ethnicity and sex.


In this retrospective study, we analyzed data collected from the medical records of 1487 vitiligo patients seen at New York University during a 10-year period.


Vitiligo patients had a statistically significant higher prevalence of hypothyroidism, multiple sclerosis, rheumatoid arthritis, idiopathic thrombocytopenic purpura, seronegative arthritis, pernicious anemia, myasthenia gravis, inflammatory bowel disease, lymphoma, and systemic lupus erythematosus. Rates of comorbid autoimmune diseases varied by race and sex.


Medical charts did not consistently report race/ethnicity, type of vitiligo, and total body surface area affected. Information from nondermatology medical visits was also included.


This study revealed multiple new disease associations for vitiligo, including multiple sclerosis, idiopathic thrombocytopenic purpura, and lymphoma, as well as confirmed previously reported associations with other autoimmune diseases, the most common being hypothyroidism followed by rheumatoid arthritis. Associations did vary by race/ethnicity and sex.

The full text of this article is available in PDF format.

Key words : associations, autoimmunity, comorbid diseases, demographics, laboratory values, vitiligo

Abbreviations used : ITP, TFT

 Funding sources: None.
 Conflicts of interest: None disclosed.

© 2019  American Academy of Dermatology, Inc.@@#104156@@
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