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Journal of the American Academy of Dermatology
Sous presse. Epreuves corrigées par l'auteur. Disponible en ligne depuis le mardi 27 août 2019
Doi : 10.1016/j.jaad.2019.08.001
accepted : 2 August 2019
Prevalence estimates for pyoderma gangrenosum in the United States: An age- and sex-adjusted population analysis
 

Amy Xu, MD, MA, Amrita Balgobind, BA, Andrew Strunk, MA, Amit Garg, MD, Allireza Alloo, MD
 Department of Dermatology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, New York 

Correspondence to: Allireza Alloo, MD, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, 1991 Marcus Ave, Ste 300, New Hyde Park, NY 11042.Donald and Barbara Zucker School of Medicine at Hofstra/Northwell1991 Marcus AveSte 300New Hyde ParkNY11042
Abstract
Background

The disease burden of pyoderma gangrenosum (PG) is poorly understood.

Objective

To determine standardized overall and age-, sex-, and race-specific prevalence estimates for PG among adults in the United States.

Methods

Cross-sectional analysis of 1971 patients with PG identified using electronic health records data from a diverse population-based sample of more than 58 million patients.

Results

The age- and sex-standardized prevalence of PG among the study population was 0.0058%, or 5.8 PG cases (95% confidence interval [CI], 5.6-6.1) per 100,000 adults. Adjusted prevalence was nearly twice as high among women (7.1 cases [95% CI, 6.7-7.5] per 100,000) than men (4.4 cases [95% CI, 4.0-4.7] per 100,000). Patients between the ages of 70 and 79 years had the highest standardized prevalence (9.8 cases [95% CI, 8.8-10.9] per 100,000), with patients aged ≥50 years representing nearly 70% of all PG cases. Standardized prevalence was similar among white and African American patients. The female-to-male ratio of PG was >1.8 across all age groups.

Limitations

Analysis of electronic health records data may result in misclassification bias.

Conclusion

PG is a rare disease that most commonly affects women and those aged ≥50 years.

The full text of this article is available in PDF format.

Key words : epidemiology, female, prevalence, pyoderma gangrenosum

Abbreviations used : CI, IBD, ICD, IL, PG, SNOMED-CT, US



 Funding sources: None
 Conflicts of interest: Dr Garg has served as an advisor for AbbVie, Amgen, Janssen, Pfizer, UCB, and Asana Biosciences, and has received honoraria. Dr Alloo serves as a consultant for Gemstone Biotherapeutics. Authors Xu, Balgobind, and Strunk have no conflicts of interest to report.



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