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Journal of the American Academy of Dermatology
Sous presse. Epreuves corrigées par l'auteur. Disponible en ligne depuis le vendredi 11 octobre 2019
Doi : 10.1016/j.jaad.2019.08.027
accepted : 10 August 2019
Prognostic value of inositol polyphosphate-5-phosphatase expression in recurrent and metastatic cutaneous squamous cell carcinoma
 

Connor J. Maly, BS a, Helen J.L. Cumsky, MD a, Collin M. Costello, MD a, Jessica E. Schmidt, MS a, Richard J. Butterfield, MS b, Nan Zhang, MS b, David J. DiCaudo, MD a, Steven A. Nelson, MD a, Maxwell L. Smith, MD c, Shari A. Ochoa, MD a, Christian L. Baum, MD d, Thomas H. Nagel, MD e, Mark R. Pittelkow, MD a, Aleksandar Sekulic, MD, PhD a, Aaron R. Mangold, MD a,
a Department of Dermatology, Mayo Clinic, Scottsdale, Arizona 
b Department of Health Science Research, Mayo Clinic, Scottsdale, Arizona 
c Department of Pathology, Mayo Clinic, Scottsdale, Arizona 
d Department of Dermatology, Mayo Clinic, Rochester, Minnesota 
e Department of Otolaryngology, Mayo Clinic, Scottsdale, Arizona 

Correspondence to: Aaron R. Mangold, MD, Mayo Clinic Department of Dermatology, 13400 E Shea Blvd, Scottsdale, AZ 85259.Mayo Clinic Department of Dermatology13400 E Shea BlvdScottsdaleAZ85259
Abstract
Background

Inositol polyphosphate-5-phosphatase (INPP5A) has been shown to play a role in the progression of actinic keratosis to cutaneous squamous cell carcinoma (cSCC) and the progression of localized disease to metastatic disease. Currently, no cSCC biomarkers are able to risk stratify recurrent and metastatic disease.

Objective

To determine the prognostic value of INPP5A expression in cSCC recurrent and metastatic disease.

Methods

We conducted a multicenter, single-institutional, retrospective cohort study within the Mayo Clinic Health System on the use of immunohistochemical staining to examine cSCC INPP5A protein expression in primary tumors and recurrent and metastatic disease. Dermatologists and dermatopathologists were blinded to outcome.

Results

Low staining expression of INPP5A in recurrent and metastatic disease tumors was associated with poor overall survival (OS) (31.0 months for low versus 62.0 months for high expression; P  = .0272). A composite risk score (calculated as score of primary tumor + score of recurrent or metastatic disease tumor, with tumors with high expression scoring a zero and low expression a 1, score range 0-2) of 0 was predictive of improved OS compared with a composite risk score of ≥1 (hazard ratio 0.42, 95% confidence interval 0.21-0.84; P  = .0113).

Limitations

This is a multicenter but single institution study of a white population.

Conclusion

Loss of INPP5A expression predicts poor OS in recurrent and metastatic disease of cSCC.

The full text of this article is available in PDF format.

Key words : IHC, immunohistochemistry, inositol polyphosphate-5-phosphatase, INPP5A, SCC, squamous cell carcinoma

Abbreviations used : BWH, CRS, cSCC, HR, HSE, INPP5A, LR, LSE, OS, SCC



 Funding sources: Supported by a Dermatology Foundation Career Development Award and the National Institutes of Health (grant no. 5R01CA179157).
 Conflicts of interest: None disclosed.
 Previously presented at the Society for Investigative Dermatology 77th annual meeting in Chicago, Illinois, May 8-11, 2019.
 Reprints not available from the authors.



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