The impact of environmental ultraviolet exposure on the clinical course of mycosis fungoides - 11/10/19
, Sameer Desale, MS b, Stephen J. Fernandez, MPH b, Aarthi G. Shenoy, MD cAbstract |
Background |
As phototherapy plays an important role in the treatment of early-stage mycosis fungoides (MF), it is possible that environmental ultraviolet (UV) exposure affects the natural history of the disease.
Objective |
To assess the impact of environmental UV exposure on the clinical course of MF.
Methods |
The National Solar Radiation Database was used to identify the top and bottom registries for UV exposure from the Surveillance, Epidemiology, and End Results–18 database. Incidence and survival were determined.
Results |
The high-UV cohort had a 30% lower risk of developing MF than did the low-UV cohort (hazard ratio, 1.3; 95% confidence interval, 1.20-1.41; P < .001). When stratified by stage and race, this difference was appreciable only among those with early-stage disease and white race. There was no difference in survival between the high- and low-UV cohorts (P = .098); however, a small difference was observed among those with early-stage disease and white race, favoring high UV exposure.
Limitations |
Retrospective design, use of the National Solar Radiation Database as a surrogate for individual sunlight exposure.
Conclusion |
It is possible that environmental solar UV exposure may play a role in controlling early-stage MF among patients with photosensitive features.
Le texte complet de cet article est disponible en PDF.Key words : mycosis fungoides, phototherapy, ultraviolet light
Abbreviations used : MF, nb-UVB, NSRB, PUVA, SEER, SS, UV, UVA, UVB
Plan
| Funding sources: None. |
|
| Conflicts of interest: None disclosed. |
|
| The opinions and assertions expressed herein are those of the author(s) and do not necessarily reflect the official policy or position of the Uniformed Services University or the Department of Defense. |
|
| Reprints not available from the authors. |
Vol 81 - N° 5
P. 1074-1077 - novembre 2019 Retour au numéro
Article précédent
- Contemplating the navel: Omphalomesenteric duct remnant disorders
- Warren R. Heymann
- Galactose-deficient IgA1 in skin and serum from patients with skin-limited and systemic IgA vasculitis
- Matthias Neufeld, Karen Molyneux, Karin I. Pappelbaum, Sarah Mayer-Hain, Christina von Hodenberg, Jan Ehrchen, Jonathan Barratt, Yusuke Suzuki, Cord Sunderkötter
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?