Galactose-deficient IgA1 in skin and serum from patients with skin-limited and systemic IgA vasculitis - 11/10/19
Abstract |
Background |
IgA vasculitis (IgAV) encompasses a systemic form involving kidneys, gut, skin, or joints, and a skin-limited form. One characteristic feature of systemic IgAV is deposition of galactose-deficient IgA1 (GD-IgA1) in kidneys (as in IgA nephropathy). The relevance of GD-IgA1 for cutaneous vasculitis is unknown.
Objective |
We investigated whether GD-IgA1 is deposited perivascularly in systemic and also skin-limited IgAV and whether its serum levels differ between both forms.
Methods |
In a case-control study, deposition of GD-IgA1 was analyzed immunohistochemically by KM55 antibody in skin biopsy specimens from 12 patients with skin-limited IgAV and 4 with systemic IgAV. GD-IgA1 levels were compared by enzyme-linked immunosorbent assay in sera from 15 patients each with skin-limited and systemic IgAV and from 11 healthy individuals.
Results |
All biopsy samples from systemic IgAV, and also from skin-limited IgAV, revealed perivascular GD-IgA1 deposition. The average GD-IgA1 concentration in serum was significantly higher in systemic IgAV than in skin-limited IgAV, despite overlap between the groups.
Limitations |
Although high GD-IgA1 levels may be predictive of systemic IgAV, patient numbers were too low to determine cutoff values for systemic versus skin-limited IgAV.
Conclusion |
Perivascular GD-IgA1 deposition is a prerequisite for systemic and skin-limited IgAV; however, high GD-IgA1 levels in some patients with systemic IgAV suggest a dose-dependent effect of GD-IgA1 in IgAV.
Le texte complet de cet article est disponible en PDF.Key words : dermatology, galactose-deficient IgA1, GD-IgA1, Henoch Schönlein purpura, IgA nephropathy, IgA vasculitis, IgA vasculitis with nephritis, IgAVN
Plan
Funding sources: This work was partially supported by grants from “Innovative Medical Research” (IMF) Muenster Medical School, Muenster University (Grant number: PA 1 1 15 15). |
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Conflicts of interest: None disclosed. |
Vol 81 - N° 5
P. 1078-1085 - novembre 2019 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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