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Journal of the American Academy of Dermatology
Sous presse. Epreuves corrigées par l'auteur. Disponible en ligne depuis le jeudi 31 octobre 2019
Doi : 10.1016/j.jaad.2019.03.016
accepted : 8 Mars 2019
Comparison of a picosecond alexandrite laser versus a Q-switched alexandrite laser for the treatment of nevus of Ota: A randomized, split-lesion, controlled trial
 

Yiping Ge, MD, PhD, Ying Yang, MD, Lifang Guo, MD, Mengli Zhang, MD, PhD, Qiuju Wu, MD, Rong Zeng, MD, PhD, Huizhen Rong, BSN, Gaorong Jia, BSN, Hualing Shi, BSN, Jing Fang, BSN, Tong Lin, MD, PhD
 Department of Cosmetic Laser Surgery, Hospital for Skin Disease and Institute of Dermatology, Peking Union Medical College and Chinese Academy of Medical Sciences, Nanjing, China 

Reprint requests: Tong Lin, MD, PhD, Department of Cosmetic Laser Surgery, Hospital for Skin Disease and Institute of Dermatology, Peking Union Medical College and Chinese Academy of Medical Sciences, Nanjing 210042, China.Department of Cosmetic Laser SurgeryHospital for Skin Disease and Institute of DermatologyPeking Union Medical College and Chinese Academy of Medical SciencesNanjing210042China
Abstract
Background

Novel picosecond lasers have been available for various pigmentary disorders. However, there are limited data directly comparing picosecond lasers and Q-switched lasers for treatment of nevus of Ota.

Objective

To compare the efficacy and safety of a picosecond alexandrite laser (PSAL) with a Q-switched alexandrite laser (QSAL) for the treatment of nevus of Ota.

Methods

Each lesion of 56 enrolled participants was split into 2 parts and randomly assigned to either the PSAL or QSAL treatment arm. Each lesion was treated in up to 6 sessions in 12-week intervals. Efficacy and safety were determined using blinded visual evaluation and self-report at each follow-up visit.

Results

The PSAL arm achieved a significantly better clearance (5-point scale, PSAL 4.53 vs QSAL 4.0) with fewer sessions (PSAL 5.26 vs QSAL 5.87) and less severe pain (Visual Analog Scale, PSAL 5.61 vs QSAL 6.40). Patients were more satisfied with PSAL than QSAL (Likert scale, 4.5 vs 4.0). Occurrences of postinflammatory hyperpigmentation (PSAL 26% vs QSAL 34%) and hypopigmentation (PSAL 21% vs QSAL 47%) were also lower in PSAL than QSAL arm.

Limitations

Lack of objective assessments and outcome measures.

Conclusion

PSAL demonstrated better clinical results and fewer adverse events than QSAL for the treatment of nevus of Ota.

The full text of this article is available in PDF format.

Key words : nevus of Ota, photomechanical effect, picosecond alexandrite laser, postinflammatory hypopigmentation, Q-switched alexandrite laser, split-lesion

Abbreviations used : PIH, PIHo, PSAL, QSAL, SD



 Funding sources: Supported by Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences (no. CIFMS-2017-I2M-1-017) and Key Research and Development Plans of Jiangsu Province (no. BE2017808).
 Conflicts of interest: None disclosed.



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