What is the impact of outdoor pollution on children's asthma? - 06/11/19

Doi : 10.1016/j.arcped.2019.10.007

V. Houdouin ^a,⁎ , J.-C. Dubus ^b
^a Inserm U 1149, équipe INSIGHT, service de pneumologie et d’allergologie pédiatrique, hôpital universitaire Robert-Debré, 48, boulevard Serrurier, 75019 Paris, France
^b Unité de pneumo-allergologie pédiatrique, IRD, MEPHI, IHU-Méditerranée Infection, Aix Marseille Université, AP-HM, CHU de Timone-Enfants, 264, rue Saint-Pierre, 13385 Marseille cedex 5, France

^⁎Corresponding author: Inserm U 1149, équipe INSIGHT, service de pneumologie et d’allergologie pédiatrique, hôpital universitaire Robert-Debré, 48, boulevard Serrurier, 75019 Paris, France.Inserm U 1149, équipe INSIGHT, service de pneumologie et d’allergologie pédiatrique, hôpital universitaire Robert-Debré48, boulevard SerrurierParis75019France

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Abstract

Outdoor pollution is a complex mix of more than 200 air contaminants. Among these pollutants, ozone, nitrogen dioxide and fine particles may generate bronchial inflammation and hyperreactivity. The hypothesis that pollution contributes to the development of asthma in children is based on epidemiological, clinical and experimental data. Many risk factors during the in utero and postnatal period have been identified in the aetiology of childhood asthma. During pregnancy, outdoor pollution was identified as a causal factor of respiratory disease in neonatal cohort studies. Several epidemiological studies also demonstrate that outdoor pollution is a trigger of asthma exacerbations. This review aims to highlight the current knowledge on outdoor pollution and asthma.

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Keywords : Outdoor pollution, Ozone, Nitrogen Oxides, Particulate matters, Asthma, Children