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Journal of the American Academy of Dermatology
Sous presse. Epreuves corrigées par l'auteur. Disponible en ligne depuis le mardi 12 novembre 2019
Doi : 10.1016/j.jaad.2019.07.097
Efficacy and safety of methotrexate versus placebo as add-on therapy to H1 antihistamines for patients with difficult-to-treat chronic spontaneous urticaria: A randomized, controlled trial

Sophie Leducq, MD a, b, c, , Mahtab Samimi, MD, PhD a, d, Claire Bernier, MD e, Angèle Soria, MD f, Emmanuelle Amsler, MD f, Delphine Staumont-Sallé, MD, PhD g, Germaine Gabison, MD h, Olivier Chosidow, MD, PhD h, Nathalie Bénéton, MD i, Corina Bara, MD i, Anne Grange-Prunier, MD j, Ewa Wierzbicka-Hainaut, MD k, Emilie Brenaut, MD l, Catherine Droitcourt, MD m, Nathalie Raison-Peyron, MD n, Hélène Bourgoin, MD o, Hélène Cornillier, MD a, Laurent Machet, MD, PhD a, Bruno Giraudeau, PhD b, c, Agnès Caille, MD b, c, Annabel Maruani, MD, PhD a, c
a Department of Dermatology, University Hospital of Tours, Tours, France 
b Clinical Investigation Center, INSERM CIC 1415, University Hospital of Tours, Tours, France 
c Université de Tours, Université de Nantes, INSERM U1246-SPHERE, France 
d ISP 1282 INRA, University of Tours, Tours, France 
e Department of Dermatology, University Hospital Center of Nantes, Nantes, France 
f Department of Dermatology and Allergology, Hospital Tenon, Paris, Assistance Publique Hopitaux de Paris, Sorbonne Université, Paris, France 
g CHU Lille, Service de dermatologie et vénérologie, F-59000 Lille, France, Univ. Lille, Inserm U995 - LIRIC - Lille Inflammation Research International Center, F-59000 Lille, France 
h Department of Dermatology, Assistance Publique Hôpitaux de Paris, Henri-Mondor Hospital, Créteil, France 
i Department of Dermatology, Hospital Center of le Mans, le Mans, France 
j Department of Dermatology, Reims University Hospital, University of Reims-Champagne-Ardenne, Reims, France 
k Department of Dermatology, University Hospital of Poitiers, Poitiers, France 
l Department of Dermatology, University Hospital of Brest, Brest, France 
m Department of Dermatology, University Hospital of Rennes, Rennes, France 
n Department of Dermatology, University Hospital of Montpellier, Montpellier, France 
o Department of Pharmacy, University Hospital of Tours, Tours, France 

Correspondence to: Sophie Leducq, MD, Department of Dermatology, Centre Hospitalier Regional Universitaire de Tours, Avenue de la République, 37044 Tours CEDEX 9, FranceDepartment of DermatologyCentre Hospitalier Regional Universitaire de ToursAvenue de la RépubliqueTours CEDEX 937044France

 Dr Leducq, Dr Samimi, and Dr Maruani contributed to this work equally.
 Funding sources: Supported by the French Ministry of Social Affairs and Health (French National Programme of Clinical Research 2009).
 Conflicts of interest: Pr Samimi has received speaking fees for an educational program from BMS, Janssen, Acthelion, and AbbVie. Dr Soria has received honoraria for serving as a speaker, an advisor, and a consultant from Novartis. Dr Amsler has received honoraria for serving as a speaker and an advisor from Novartis. Pr Staumont-Sallé has received fees for serving as an advisor or a speaker from Janssen, Novartis, Sanofi, Pfizer, AbbVie, and Lilly and has received research funding for serving as a principal investigator from Galderma, Leo Pharma, Novartis, and Lilly. Dr Wierzbicka-Hainaut has received honoraria for serving as an advisor for Novartis and Sanofi. Dr Raison-Peyron has received honoraria for serving as a speaker and principal investigator from Novartis and has received equipment from Novartis. Dr Leducq, Dr Bernier, Dr Gabison, Pr Chosidow, Dr Bénéton, Dr Bara, Dr Grange-Prunier, Dr Brenaut, Dr Droitcourt, Dr Bourgoin, Dr Cornillier, Pr Machet, Pr Giraudeau, Dr Caille, and Pr Maruani have no conflicts of interest to disclose.
 Previously presented at the 24th World Congress of Dermatology on June 10-15, 2019, in Milan, Italy.
 Reprints not available from the authors.

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