Osseous sarcoidosis: A multicenter retrospective case-control study of 48 patients - 15/11/19
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Highlights |
• | Osseous sarcoidosis is frequently asymptomatic and incidentally detects in half of the patients. |
• | Patients with osseous sarcoidosis have higher rates of thoracic and extra-thoracic lymph nodes, pulmonary and cutaneous involvement, and hypercalcemia. |
• | Therapeutic response to corticosteroids is good in combination with methotrexate or hydroxychloroquin. |
Abstract |
Objective |
To describe the clinical presentation, distribution of lesions, treatment, and outcomes of osseous sarcoidosis.
Methods |
A French retrospective multicenter study of patients with biopsy-proven sarcoidosis analyzed patients with 1) a biopsy-proven granuloma without caseous necrosis, and either 2) osseous clinical manifestations, or 3) abnormal osseous imaging. Sarcoidosis patients with osseous involvement (cases) were compared with 264 age- and sex-matched sarcoidosis patients with no osseous manifestations (controls).
Results |
In the osseous sarcoidosis group (n=88), forty-two (48%) patients had osseous-related symptoms involving the axial (69%) and/or appendicular (58%) skeleton. On imaging, the most commonly affected bones were in the spine (52%), pelvis (42%), hands (22%) and femur (19%). Compared with controls, cases had higher rates of mediastinal (93% vs. 47%) and extra-thoracic lymph node involvement (66% vs. 21%), pulmonary (90% vs. 65%) and cutaneous involvement (44% vs. 23%) (all P<0.0001), and hypercalcemia (8.5% vs. 2%, P=0.014). Spleen/liver and gastrointestinal involvement were less frequent in the osseous sarcoidosis group (29% vs. 45%, and 1% vs. 17%, respectively, P<0.0001). Response rates to with glucocorticoids alone, glucocorticoids plus methotrexate or glucocorticoids plus hydroxychloroquine were 23/44 (52%), 9/13 (69%) and 4/6 (67%), respectively.
Conclusion |
In patients with osseous sarcoidosis the spine and pelvis were the most commonly affected bones. Compared with controls, cases with osseous sarcoidosis have higher rates of thoracic and extra-thoracic lymph node involvement, pulmonary and cutaneous involvement, and hypercalcemia. Most patients with osseous sarcoidosis had a good response to glucocorticoids in combination with methotrexate or hydroxychloroquine.
Le texte complet de cet article est disponible en PDF.Keywords : Sarcoidosis, Osseous manifestations, Bone involvement
Plan
Vol 86 - N° 6
P. 789-793 - novembre 2019 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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