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Journal of the American Academy of Dermatology
Sous presse. Epreuves corrigées par l'auteur. Disponible en ligne depuis le jeudi 19 décembre 2019
Doi : 10.1016/j.jaad.2019.07.012
accepted : 2 July 2019
The incidence rates and risk factors of Parkinson disease in patients with psoriasis: A nationwide population-based cohort study
 

Ji Hyun Lee, MD, PhD a, , Kyungdo Han, PhD b, Heon Yung Gee, MD, PhD c,
a Department of Dermatology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea 
b Department of Medical Statistics, College of Medicine, The Catholic University of Korea, Seoul, Korea 
c Department of Pharmacology, Brain Korea 21 PLUS Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Korea 

Reprint requests: Heon Yung Gee, MD, PhD, Department of Pharmacology, Brain Korea 21 PLUS Project for Medical Sciences, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.Department of PharmacologyBrain Korea 21 PLUS Project for Medical SciencesYonsei University College of MedicineSeoul03722Republic of KoreaJi Hyun Lee, MD, PhD, Department of Dermatology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, 06591, Korea.Department of DermatologySeoul St. Mary's HospitalCollege of MedicineThe Catholic University of KoreaSeoul06591Korea
Abstract
Background

The association between psoriasis and Parkinson disease has not been established.

Objective

To determine the incidence rates and risk factors of Parkinson disease in patients with psoriasis.

Methods

We conducted a nationwide population-based cohort study. The data from patients with psoriasis (N = 548,327, ≥20 years of age, 53.32% men and 46.68% women) and age- and sex-matched control patients (N = 2,741,635) without psoriasis were analyzed in this study.

Results

The incidence rates of Parkinson disease per 1000 person-years were 0.673 and 0.768 in the control and psoriasis groups, respectively. The psoriasis group showed a significantly increased risk of developing Parkinson disease (hazard ratio [HR] 1.091, 95% confidence interval [CI] 1.029-1.115). The risk of Parkinson disease was significantly higher among the psoriasis patients who were not receiving systemic therapy (HR 1.093, 95% CI 1.031-1.159) and lower among the psoriasis patients on systemic therapy (HR 1.04, 95% CI 0.806-1.316).

Limitations

The limitations of this study included the retrospective design, patient inclusion solely on the basis of diagnostic codes, and unavailability of data on confounding factors.

Conclusion

Systemic anti-inflammatory agents might mitigate the risk of Parkinson disease in psoriasis patients.

The full text of this article is available in PDF format.

Key words : cohort study, incidence, Parkinson disease, population-based, psoriasis, risk factor

Abbreviations used : CI, HR, ICD-10, IL, NHIS, PD, RXR, TH 1, TH 17, TNF-α



 Funding sources: Supported by the National Research Foundation of Korea grant funded by the Korea government (nos. NRF-2018R1A2B6002952, 2018R1D1A1B07044100, and 2018R1A5A2025079).
 Conflicts of interest: None disclosed.



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