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Sous presse. Epreuves corrigées par l'auteur. Disponible en ligne depuis le mercredi 8 janvier 2020
Doi : 10.1016/j.therap.2019.12.007
Received : 18 October 2019 ;  accepted : 12 December 2019
Use of triptans during pregnancy? With caution!

Isabelle Lacroix a, , Caroline Hurault-Delarue a, Delphine Viard b, Bruno Revol c, Lemya Chaalel a, Christine Damase-Michel a
a Service de pharmacologie médicale et clinique, centre régional de pharmacovigilance, faculté de médecine, Inserm 1027, 31000 Toulouse, France 
b Centre régional de pharmacovigilance, hôpital de Cimiez, 06003 Nice, France 
c Centre Régional de Pharmacovigilance, CHU Grenoble, Grenoble, France 

Corresponding author. Service de pharmacologie médicale et clinique, CHU de Toulouse, faculté de médecine, 37, allées Jules-Guesde, 31000 Toulouse, France.Service de pharmacologie médicale et clinique, CHU de Toulouse, faculté de médecine37, allées Jules-GuesdeToulouse31000France

We report cases, registered in the French national pharmacovigilance database, of fetal death and intrauterine growth retardation in women exposed to triptans during pregnancy. Triptans have vasoconstrictive properties and we wonder about their responsibility for these side effects. The use of triptans and other drugs exhibiting vasoconstrictive properties in pregnant women requires a careful benefits/risks evaluation.

The full text of this article is available in PDF format.

Keywords : Drugs, Triptans, Pregnancy, Fetal death, Intra-uterine growth retardation

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