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Archives de pédiatrie
Sous presse. Epreuves corrigées par l'auteur. Disponible en ligne depuis le vendredi 17 janvier 2020
Doi : 10.1016/j.arcped.2019.12.005
Received : 22 May 2019 ;  accepted : 30 December 2019
Metabolic disturbances and cardiovascular risk factors in obese children with vitamin D deficiency
 

R. Colak a, , M. Anil b, F. Yasar c, A. Rahmi Bakiler d, O. Pirgon e, M. Helvaci f, B. Dündar g
a Dr. Behçet Uz Children's Hospital, Newborn İntensive Care Unit, İsmet Kaptan Mh., Sezer Doğan Sok. No:11, Konak/İzmir 
b Department of Pediatric Emergency, Tepecik Training and Research Hospital, Güney Mahallesi, 1140/1. Sk. No:1, 35180 İzmir, Turkey 
c Department of Radiology, Tepecik Training and Research Hospital, Güney Mahallesi, 1140/1. Sk. No:1, 35180 İzmir, Turkey 
d Department of Pediatric Cardiology, Tepecik Training and Research Hospital, Güney Mahallesi, 1140/1. Sk. No:1, 35180 İzmir, Turkey 
e Department of Pediatric Endocrinology, Süleyman Demirel University Hospital, Çünür mahallesi, Süleyman Demirel Caddesi, Merkez, Isparta, Turkey 
f Tepecik Training and Research Hospital, Güney Mahallesi, 1140/1. Sk. No:1, 35180 İzmir, Turkey 
g Department of Pediatric Endocrinology, İzmir Katip Çelebi University Hospital, Güney Mahallesi, 1140/1. Sk. No:1, 35180 İzmir, Turkey 

Corresponding author.
Abstract
Objectives

The prevalence of obesity among children and adolescents has been rapidly increasing in recent years. Obese individuals are at risk of vitamin D deficiency. The aim of this study was to investigate the relationship between vitamin D deficiency and anthropometric measurements, cardiovascular risk factors, and glucose homeostasis in obese children.

Methods

Between June 2011 and January 2012, 40 obese and 30 non-obese children (between 7 and 14 years of age) were evaluated at Tepecik Training and Research Hospital. The following characteristics were recorded: height; weight; body mass index (BMI); total body fat content; fasting glucose, insulin, and lipid levels; basic biochemical parameters; complete blood count; bilateral carotid intima media thickness; liver ultrasound results; and left ventricular wall thickness were recorded. 25-hydroxy (OH) vitamin D levels were measured from serum.

Results

The serum 25(OH) vitamin D level was low in 45 children (64.3%). The 24-h ambulatory blood pressure measurements, carotid intima-media thickness, and the prevalence of 25(OH) vitamin D deficiency were different between obese and non-obese children (P <0.05). The incidence of dyslipidemia was not statistically different between obese and non-obese children (P >0.05). Plasma 25(OH) vitamin D concentrations were negatively correlated with age, BMI, total body fat content, 24-h ambulatory blood pressure, and carotid intima-media thickness (P <0.05). Plasma 25(OH) vitamin D levels were not correlated with fasting plasma glucose, HOMA-IR, triglycerides, total cholesterol, low-density cholesterol, and high-density cholesterol (P >0.05).

Conclusion

Vitamin D deficiency is more prevalent in obese children. Serum 25(OH)vitamin D was significantly associated with several cardiometabolic risk factors. There was no relationship between abnormal glucose homeostasis and dyslipidemia with vitamin D deficiency in obese children.

The full text of this article is available in PDF format.

Keywords : Vitamin D deficiency, Obesity, Children, Cardiovascular risk factors, Insulin resistance




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