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Joint Bone Spine
Sous presse. Epreuves corrigées par l'auteur. Disponible en ligne depuis le vendredi 17 janvier 2020
Doi : 10.1016/j.jbspin.2019.11.004
Received : 18 October 2019 ;  accepted : 27 November 2019
A case of Whipple's disease mimicking auto-inflammatory disease and revealed by severe right cardiac failure under anakinra

Pauline Brevet a, , Pascal Rottenberg a, Catherine Viacroze b, Dominique Schleifer b, Thierry Lequerre a, Olivier Vittecoq a
a Rheumatology department, CHU de Rouen, 1, rue de Germont, 76000 Rouen, France 
b Pneumology department, CHU de Rouen, 147, rue de Clairière, 76230 Bois-Guillaume, France 

Corresponding author.

A Whipple's disease can mimic Still's disease.
A Whipple's disease can be unmasked by an anti-IL-1RA.
Whipple's disease can lead to pulmonary hypertension and severe heart failure.
High blood pressure and right heart failure are totally regressive under well-managed antibiotic treatment.
PCR Whipple on urine is not sensitive and should not be used (negative PCR while the patient had a disseminated disease).

The full text of this article is available in PDF format.

Keywords : Whipple disease, Anakinra, Anti-IL-1RA, Right cardiac failure, Pulmonary hypertension

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