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Journal of the American Academy of Dermatology
Sous presse. Epreuves corrigées par l'auteur. Disponible en ligne depuis le mercredi 29 janvier 2020
Doi : 10.1016/j.jaad.2019.06.013
accepted : 8 June 2019
Laser treatment of epidermal nevi: A multicenter retrospective study with long-term follow-up

Azzam Alkhalifah, MD a, b, Frederike Fransen, MD c, Florence Le Duff, MD a, Jean-Philippe Lacour, MD a, Albert Wolkerstorfer, MD, PhD c, Thierry Passeron, MD, PhD a, d,
a Department of Dermatology, CHU Nice, Université Côte d'Azur, Nice 
b Department of Dermatology, Qassim University, CHU Nice, Unaizah College of Medicine, Qassim 
c Department of Dermatology, Academic Medical Centre, University of Amsterdam 
d U1065, C3M, Institut National de la Santé et de la Recherche Médicale, Université Côte d'Azur, Nice 

Correspondence to: Thierry Passeron, MD, PhD, Dermatologie, 151 route St Antoine De Ginestiere, 06200 Nice, France.Dermatologie151 route St Antoine De GinestiereNice06200France

Patients with epidermal nevi strongly demand cosmetic improvement. Laser treatment appears appealing and is frequently used in clinical practice. Nevertheless, large series with long-term follow-up are missing, preventing definitive conclusions about its real benefit.


To evaluate the long-term effectiveness and safety of lasers for epidermal nevi.


Bicentric, retrospective, cohort study, including all patients treated with a laser for an epidermal nevus with more than a 1-year follow-up.


Seventy patients were treated for different types of epidermal nevi, mostly with ablative lasers: 23 verrucous epidermal nevi, 16 nevi sebaceous, 26 Becker nevi, 2 inflammatory linear verrucous epidermal nevi, 1 smooth-muscle hamartoma, 1 rounded and velvety epidermal nevus, and 1 nevus lipomatosus superficialis. The follow-up period was a median of 37 months (range, 12-127 months). Better results, fewer recurrences, and higher patient satisfaction were noted in treatments for verrucous epidermal nevi than for nevi sebaceous. Q-switched lasers failed to show any degree of improvement in almost all patients with Becker nevus.


The retrospective nature of the study.


Ablative lasers can treat verrucous epidermal nevi with good long-term esthetic results but have limited long-term efficacy for nevus sebaceous. Q-switched lasers failed to improve Becker nevi.

The full text of this article is available in PDF format.

Key words : ablative laser, Becker nevus, CO2 laser, epidermal nevus, Er:YAG laser, ILVEN, nevus lipomatosus superficialis, nevus sebaceous, Becker's nevus, smooth-muscle hamartoma, verrucous epidermal nevus

Abbreviations used : BN, EN, Er:YAG, LT-PGA, NS, RAVEN, ST-PGA, VEN

 Funding sources: None.
 Conflicts of interest: None disclosed.
 Supplementary files are available on: 38rfzj4c2m.1.
 Reprints not available from the authors.

© 2019  American Academy of Dermatology, Inc.@@#104156@@
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