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Journal of the American Academy of Dermatology
Sous presse. Epreuves corrigées par l'auteur. Disponible en ligne depuis le lundi 3 février 2020
Doi : 10.1016/j.jaad.2019.06.024
accepted : 11 June 2019
Psoriatic lesions are characterized by higher bacterial load and imbalance between Cutibacterium and Corynebacterium
 

Cheng Quan, MD, PhD a, b, Xiao-Ying Chen, MD a, Xia Li, MD, PhD a, , Feng Xue, PhD b, Li-Hong Chen, MD, PhD a, Na Liu, MD b, Bo Wang, MD, PhD a, Lan-Qi Wang, MD, PhD b, Xiao-Pan Wang, MD b, Hui Yang, MD b, Jie Zheng, MD, PhD b,
a Department of Dermatology, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China 
b Laboratory of Dermatoimmunology, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China 

Correspondence to: Jie Zheng, MD, PhD and Xia Li, MD, PhD, Shanghai Jiaotong University, Department of Dermatology, 197 Ruijin er Rd, Shanghai 200025, China.Shanghai Jiaotong UniversityDepartment of Dermatology197 Ruijin er RdShanghai200025China
Abstract
Background

Several studies have found that the microbiota of psoriatic lesions is different from that of healthy skin.

Objective

To characterize the microbiota of lesional and unaffected skin in patients with psoriasis and controls and investigate the correlation between cutaneous microbiota and clinical features of psoriasis.

Methods

Using quantitative polymerase chain reaction and 16S rRNA sequencing, we assayed the profiles of cutaneous microbiota in controls, unaffected skin, and psoriatic lesions. We also investigated the correlation of psoriasis-associated taxa with clinical characteristics.

Results

High bacterial load was identified in the psoriatic lesions compared with unaffected skin and controls. There was an imbalance between Cutibacterium (also known as Propionibacterium ) and Corynebacterium in psoriatic skin. Lesions showed a higher proportion of Corynebacterium and a lower proportion of Cutibacterium compared with unaffected skin and controls. Corynebacterium was correlated with the severity of local lesions, whereas Cutibacterium showed correlation with the abnormity of skin capacitance.

Limitations

We did not conduct a longitudinal study.

Conclusions

Psoriatic lesions are characterized by higher bacterial load and imbalance between Cutibacterium and Corynebacterium .

The full text of this article is available in PDF format.

Key words : bacterial load, Corynebacterium , Cutibacterium , psoriasis

Abbreviations used : CAP, Cr , Cu , FDR, PASI, PCR, ROC curve



 Drs Quan and Chen contributed equally to this work.
 Funding sources: This work was supported by Special Fund of National Excellent Doctoral Dissertation (201479), China Postdoctoral Science Foundation (2015M571577), National Natural Science Foundation of China (91442123 and 81502718), and Foundation of National Clinical Key Department Construction Project (2012649).
 Conflicts of interest: None disclosed.
 Reprints not available from the authors.



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