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Journal of the American Academy of Dermatology
Sous presse. Epreuves corrigées par l'auteur. Disponible en ligne depuis le lundi 3 février 2020
Doi : 10.1016/j.jaad.2019.09.073
accepted : 9 September 2019
A crosslinked polymer skin barrier film for moderate to severe atopic dermatitis: A pilot study in adults
 

Melaney Bouthillette, BS a, b, , Daniela Beccati, PhD a, b, Ariya Akthakul, PhD a, b, Nithin Ramadurai, MS a, b, Amir Nashat, PhD b, Robert Langer, PhD c, d, e, f, R. Rox Anderson, MD c, g, h, Fernanda H. Sakamoto, MD, PhD g, h,
a Shiseido Americas Corporation, Cambridge, Massachusetts 
b Olivo Laboratories, LLC, Watertown, Massachusetts 
c Harvard-MIT Division of Health Science and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts 
d Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 
e David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 
f Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 
g Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts 
h Department of Dermatology, Harvard Medical School, Boston, Massachusetts 

Correspondence to: Fernanda H. Sakamoto, MD, PhD, Wellman Center for Photomedicine, Massachusetts General Hospital, Department of Dermatology, Harvard Medical School, 55 Fruit St, Thier 210, Boston, MA 02114.Wellman Center for PhotomedicineMassachusetts General HospitalDepartment of DermatologyHarvard Medical School55 Fruit St, Thier 210BostonMA02114Reprint requests: Melaney Bouthillette, BS, Shiseido Americas Corporation, One Kendall Square, 14-403, Cambridge, MA 02139.Shiseido Americas Corporation14-403CambridgeMA02139
Abstract
Background

Occlusive treatments are a mainstay in atopic dermatitis (AD) management but may not be well tolerated or lack compliance. A comfortable, semiocclusive, artificial skin barrier that is well tolerated, provides protection, and reduces water loss is needed.

Objective

To evaluate the potential tolerability and therapeutic benefits of a crosslinked polymer layer (XPL) in adults with AD.

Methods

A single-center, open-label pilot study was conducted involving 10 subjects with moderate to severe AD. Subjects applied XPL up to twice daily for 30 days on a selected treatment area. Investigator's Global Assessment, clinical signs of eczema, and pruritus were assessed on days 1, 3, 5, 15, and 30. Film durability and patient satisfaction were also evaluated.

Results

Investigator's Global Assessment scores improved from moderate to severe at baseline to clear to almost clear in 8 of 9 patients at day 30. Pruritus improved from trace to severe itching (baseline) to all subjects having trace to no itching at day 30. There was 1 adverse event of mild exudative dermatitis.

Limitations

The study was limited by small sample size, open-label design, and lack of control.

Conclusion

XPL may be an effective adjuvant in AD treatment. A larger study with a control group is warranted.

The full text of this article is available in PDF format.

Key words : atopic dermatitis, eczema, inflammatory skin diseases, itch, skin barrier function, silicone dressing

Abbreviations used : AD, BSA, IGA, XPL



 Funding sources: Supported by Olivo Laboratories, LLC.
 Disclosure: Ms Bouthillette, Drs Beccati and Akthakul, Mr Ramadurai, and Drs Nashat, Langer, Rox Anderson, and Sakamoto hold financial interest in Olivo Laboratories, LLC.
 IRB approval status: Reviewed and approved by Hummingbird IRB (2016-18).



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