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Journal of the American Academy of Dermatology
Sous presse. Epreuves corrigées par l'auteur. Disponible en ligne depuis le mardi 4 février 2020
Doi : 10.1016/j.jaad.2019.08.072
accepted : 28 August 2019
Racial differences in dermatologic conditions associated with HIV: A cross-sectional study of 4679 patients in an urban tertiary care center
 

Alexandra M. Bender, PhD a, Olive Tang, BS a, Raveena Khanna, BA a, Sonja Ständer, MD b, Sewon Kang, MD a, Shawn G. Kwatra, MD a, c,
a Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland 
b Center for Chronic Pruritus, Department of Dermatology, University of Münster, Münster, Germany 
c Hopkins Bloomberg School of Public Health, Baltimore, Maryland 

Correspondence to: Shawn G. Kwatra, MD, Cancer Research Building II, Johns Hopkins University School of Medicine, Ste 206, 1550 Orleans St, Baltimore, MD 21231.Cancer Research Building IIJohns Hopkins University School of MedicineSte 2061550 Orleans StBaltimoreMD21231
Abstract
Background

Because of reduced mortality, patients with HIV are living longer and presenting with chronic diseases. Little is known about racial differences in dermatologic conditions associated with HIV infection.

Objective

This study examines associated dermatologic conditions in a large population of patients with HIV at a tertiary care center with a diverse patient population.

Methods

Cross-sectional study of patients with HIV seen between July 14, 2013, and July 14, 2018, in a tertiary health care system. The burden of HIV-related dermatologic conditions was collected by using medical records. Patients with HIV were compared with control individuals of the same race, and significance was assessed using the chi-square test. A Bonferroni correction was performed to control for multiple hypothesis testing.

Results

The study population (N = 4679) was 64.7% male and 69% African American, with 88.7% of patients receiving antiretroviral therapy. African American patients with HIV had a greater risk of oral hairy leukoplakia (odds ratio [OR], 64.49), herpes zoster (OR, 9.27), prurigo nodularis (OR, 8.80), and squamous cell carcinoma (OR, 5.72).

Limitations

Our data describe patients seen by 1 health care system.

Conclusions

African American patients with HIV may be at increased risk for pruritic disorders compared with race-matched control individuals and white patients with HIV.

The full text of this article is available in PDF format.

Key words : antiretroviral therapy, human immunodeficiency virus, Kaposi sarcoma, oral hairy leukoplakia, prurigo nodularis, pruritus

Abbreviations used : ART, CI, OR



 Funding sources: None.
 Disclosure: Dr Kwatra is an advisory board member for Menlo and Trevi Therapeutics and has grant funding from Kiniksa Pharmaceuticals. Dr Sewon Kang is an advisory board member of Almirall, Menlo, Sun Pharma, and Unilever. Drs Bender and Ständer, Ms Tang, and Ms Khanna have no conflicts of interest to declare.
 IRB approval status: Waived because only anonymous aggregate-level data counts were used.
 Reprints not available from the authors.



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