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Journal of the American Academy of Dermatology
Sous presse. Epreuves corrigées par l'auteur. Disponible en ligne depuis le jeudi 6 février 2020
Doi : 10.1016/j.jaad.2019.11.057
accepted : 22 November 2019
Measurement properties of the Patient-Reported Outcomes Measurement Information System Itch Questionnaire item banks in adults with atopic dermatitis

Jonathan I. Silverberg, MD, PhD, MPH a, b, c, d, e, , Jin-Shei Lai, PhD b, Paras P. Vakharia, MD, PharmD a, Kevin Patel, MD a, Vivek Singam, MD a, Rishi Chopra, MD, MS a, Ryan Sacotte, MD a, Neha Patel, BS a, Supriya Rastogi, MD a, Robert Kantor, MD a, Derek Y. Hsu, MD a, David Cella, PhD b, c, f
a Department of Dermatology, Feinberg School of Medicine at Northwestern University, Chicago, Illinois 
b Department of Medical Social Sciences, Feinberg School of Medicine at Northwestern University, Chicago, Illinois 
c Department of Preventive Medicine, Feinberg School of Medicine at Northwestern University, Chicago, Illinois 
d Northwestern Medicine Multidisciplinary Eczema Center, Chicago, Illinois 
e Department of Dermatology, The George Washington University School of Medicine and Health Sciences, Washington, DC 
f Department Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois 

Correspondence to: Jonathan I. Silverberg, MD, PhD, MPH, The George Washington University School of Medicine and Health Sciences, Department of Dermatology, Ste 2B-425 2150 Pennsylvania Ave, Washington, DC 20037.The George Washington University School of Medicine and Health SciencesDepartment of DermatologySte 2B-425 2150 Pennsylvania AveWashingtonDC20037

The Patient-Reported Outcomes Measurement Information System (PROMIS) Itch Questionnaire (PIQ) was recently developed.


To validate PIQ short forms in adults with AD.


Self-administered questionnaires and skin examinations were performed in 239 adults with atopic dermatitis (AD) in a dermatology practice setting.


PIQ items had good content validity. PIQ item bank T-scores strongly correlated with each other, moderately correlated with numeric and verbal rating scales for worst or average itch and with itch frequency, moderately to strongly correlated with patient-oriented eczema measure, and weakly to moderately correlated with the Eczema Area and Severity Index and Objective-Scoring AD (Spearman correlations, P  < .0001). There were significant and stepwise increases of T-scores for all item banks with increasing patient-reported global severity (Wilcoxon rank sum test, P  < .0001). However, there was limited ability to discriminate between the lowest or highest 2 levels of AD or itch severity. Item banks showed good internal consistency (Cronbach α, 0.91-0.95). No differential item functioning was identified by age, sex, race/ethnicity, or educational level. There were floor effects for total scores, particularly in almost clear/mild AD or itch.


Single-center study.


PIQ item bank short forms showed good content and construct validity and are feasible for potential use in clinical trials and practice.

The full text of this article is available in PDF format.

Key Words : atopic dermatitis, burden, eczema, itch, patient-reported outcomes, quality of life, severity, pruritus

Abbreviations used : 5D-Itch, AD, ClinRO, DIF, DLQI, EASI, NRS, oSCORAD, PIQ, POEM, PRO, QOL, SCORAD, SD, SF, VRS

 Funding sources: Supported by the Agency for Healthcare Research and Quality grant K12 HS023011, the Dermatology Foundation, and a research grant from Galderma.
 Conflicts of interest: None disclosed.
 IRB approval status: Reviewed and approved by the IRBs of Northwestern University.
 Reprints not available from the authors.

© 2019  American Academy of Dermatology, Inc.@@#104156@@
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