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Journal of the American Academy of Dermatology
Sous presse. Epreuves corrigées par l'auteur. Disponible en ligne depuis le vendredi 7 février 2020
Doi : 10.1016/j.jaad.2019.11.039
accepted : 20 November 2019
Association between psoriasis and celiac disease: A systematic review and meta-analysis
 

Prakash Acharya, MBBS, MD , Mahesh Mathur, MD, DCP
 Department of Dermatology, College of Medical Sciences, Bharatpur, Nepal 

Correspondence to: Prakash Acharya, MBBS, MD, Department of Dermatology, College of Medical Sciences, Bharatpur, Nepal, 44200.Department of DermatologyCollege of Medical SciencesBharatpur44200Nepal
Abstract
Background

Multiple studies have examined the association between psoriasis and celiac disease (CD). However, these studies have shown conflicting results.

Objective

To analyze the association between psoriasis and CD.

Methods

We conducted a systematic review of the case-control, cross-sectional, and cohort studies examining the association between psoriasis and CD in the PubMed, Scopus, and Cochrane databases. The adjusted effect sizes or crude data were extracted for quantitative analysis.

Results

Of 754 citations initially identified, 18 studies were included. Random effects meta-analysis found significant odds ratios of 2.16 (95% confidence interval, 1.74-2.69; 9 studies) for CD in patients with psoriasis and 1.8 (95% confidence interval, 1.36-2.38; 8 studies) for psoriasis in patients with CD. We also found a significantly increased risk of new-onset psoriasis in CD (hazard ratio, 1.75; 95% confidence interval, 1.58-1.93). Subgroup analyses according to disease severity and geographic region could not be performed due to limited data.

Conclusion

This 2-way meta-analysis found a significant association between psoriasis and CD. Clinicians should be aware of this association. Patients with psoriasis with bowel complaints might benefit from screening for CD through questionnaires or interviews with subsequent gastroenterology consultation.

The full text of this article is available in PDF format.

Key words : association, celiac disease, celiac sprue, meta-analysis, psoriasis, psoriatic arthritis

Abbreviations used : CD, CI, HR, OR



 Funding sources: None.
 Conflicts of interest: None disclosed.
 IRB approval status: Not applicable.
 Reprints not available from the authors.



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