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Joint Bone Spine
Sous presse. Epreuves corrigées par l'auteur. Disponible en ligne depuis le mardi 11 février 2020
Doi : 10.1016/j.jbspin.2020.01.010
accepted : 23 January 2020
Chronic bursitis and tenosynovitis revealing Whipple's disease

Jean-Jacques Dubost , Marion Couderc, Sylvain Mathieu, Anne Tournadre, Martin Soubrier
 Department of Rheumatology, CHU Clermont ferrand, 58 rue Montalembert, 63003 Clermont Ferrand Cedex 1, France 

Corresponding author at: Service de Rhumatologie, 58 rue Montalembert, 63003 Clermont-Ferrand Cedex 1, France.Service de Rhumatologie58 rue MontalembertClermont-Ferrand Cedex 163003France

Joint complaints, most commonly intermittent arthritis, are the initial manifestation in about three-fourths of Whipple's disease cases. We herein report on two cases wherein Whipple's disease manifested itself as chronic bursitis and tenosynovitis at several sites. A 42 year-old man had bilateral olecranon bursitis, a right patellar bursitis and an extensor tenosynovitis on the left wrist and a 54 year-old man had extensor tenosynovitis at both wrists and a bilateral tenosynovitis of the extensors at both ankle. Methotrexate in both patients and etanercept in one of them were not effective. Polymerase chain reaction testing revealed Tropheryma whipplei on feces, bursitis and articular fluid samples. Duodenal biopsy proved to be normal. Doxycycline and hydroxychloroquine were rapidly effective. Chronic bursitis and tenosynovitis must be added to the list of rheumatologic manifestations that may evoke the diagnosis of Whipple disease.

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Keywords : Whipple disease, Bursitis, Tenosynovitis

© 2020  Published by Elsevier Masson SAS.
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