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Journal of the American Academy of Dermatology
Sous presse. Epreuves corrigées par l'auteur. Disponible en ligne depuis le lundi 17 février 2020
Doi : 10.1016/j.jaad.2019.09.029
accepted : 17 September 2019
Male sex and Breslow thickness are important risk factors for recurrence of localized melanoma in Korean populations
 

Yeongjoo Oh, MD a, Sooyie Choi, MD a, Mi Yeon Cho, MD b, Kyoung Ae Nam, RN, MSN WOCN a, Sang Joon Shin, MD, PhD c, Jee Suk Chang, MD, PhD d, Byung Ho Oh, MD, PhD a, Mi Ryung Roh, MD, PhD b, , Kee Yang Chung, MD, PhD a,
a Department of Dermatology, Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea 
b Department of Dermatology, Gangnam Severance Hospital, Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea 
c Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Republic of Korea 
d Department of Radiation Oncology, Yonsei University College of Medicine, Seoul, Republic of Korea 

Reprint requests: Kee Yang Chung, M.D., PhD, Department of Dermatology, Cutaneous Biology Research Institute, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 120-725, Republic of Korea.Department of DermatologyCutaneous Biology Research InstituteYonsei University College of Medicine50 Yonsei-ro, Seodaemun-guSeoul120-725Republic of Korea∗∗Mi Ryung Roh, MD, PhD, Department of Dermatology, Gangnam Severance Hospital, Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.Department of DermatologyGangnam Severance HospitalCutaneous Biology Research InstituteYonsei University College of MedicineSeoulRepublic of Korea
Abstract
Background

Predicting the recurrence of localized melanoma is important; however, studies investigating risk factors for recurrence of localized melanoma are lacking in Asian populations.

Objective

To identify risk factors for recurrence of localized melanoma in Korean patients.

Methods

We retrospectively reviewed patients with cutaneous melanoma without evidence of metastasis from 2000 to 2017. Logistic and Cox regression analyses were conducted for recurrence. The average follow-up time was 46.2 months.

Results

We reviewed the data of 340 patients diagnosed with cutaneous melanoma and staged as melanoma in situ, stages I and II. Acral melanoma (70.3%, 239/340) was the predominant subtype. Ninety-two patients (27.1%) had a recurrence after primary melanoma removal (29 local recurrences, 49 regional metastases, and 28 distant metastases). Some patients had multiple types of recurrence at the same time. Male sex (P  = .030) and Breslow thickness greater than 1 mm (P  = .008) correlated with an increased risk of recurrence. Breslow thickness greater than 2.5 mm in males and greater than 4 mm in females showed a higher predictive value for recurrence than traditional stages IIB and IIC (hazard ratio 3.743 vs 2.972).

Limitations

This was a single-center retrospective study.

Conclusion

In patients with localized cutaneous melanoma, male sex and Breslow thickness are the most important prognostic factors for recurrence in Korean populations. Different cutoff values of Breslow thickness may better predict recurrence according to sex.

The full text of this article is available in PDF format.

Key words : Asian melanoma, localized melanoma, melanoma, recurrence, sex disparity

Abbreviations used : AJCC, DM, HD IFN-α, HR, LR, MMS, RFS, RM, SLNB, WE



 Funding source: Supported by a National Research Foundation of Korea grant funded by the Korea Government (MSIT) (No. 2017R1C1B2005574).
 Conflicts of interest: None disclosed.
 IRB approval status: Reviewed and approved by Yonsei University Health System; approval No. 4-2019-0027.



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