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Joint Bone Spine
Sous presse. Epreuves corrigées par l'auteur. Disponible en ligne depuis le mercredi 11 mars 2020
Doi : 10.1016/j.jbspin.2020.02.004
accepted : 12 February 2020
Patients with axial spondyloarthritis report significant differences between men and women and high impact of the disease: Large websurvey analysis
 

Sebastian E. Ibáñez Vodnizza a, , 1 , Rianne E. van Bentum b, 1, Omar Valenzuela a, Irene E. van der Horst-Bruinsma b
a Department of Rheumatology, Clínica Alemana, Universidad del Desarrollo medicine Faculty, 1410, Av. Manquehue Norte, 7650567 Vitacura, Santiago, Chile 
b Department of Rheumatology, Amsterdam University Medical Center, location VUmc, 1117, De Boelelaan, 1081HV Amsterdam, Netherlands 

Corresponding author.
Highlights

Women with axSpA in Chile report a higher levels of disease activity, daily life impairment and work disability, compared to men.
Women use less biologics despite a higher disease burden, which could suggest treatment inequality.
This study reveals the need to improve treatment access and gender inequality in Chilean axSpA.

The full text of this article is available in PDF format.
Abstract
Objective

In axial spondyloarthritis (axSpA), mounting evidence shows female patients to experience a higher disease burden. These differences appear to be particularly large in South America. One explanation could be inequity in treatment access between men and women. The objective was to evaluate gender differences in disease burden and work participation, and the potential influence of treatment, in Latin American patients.

Methods

A cross sectional online survey among axSpA patients, collecting disease characteristics, treatment, disease burden (BASDAI, BASFI, ASAS Health Index) and work participation (WPAI). Associations between gender and disease burden or work participation were assessed through regression analyses, correcting for treatment.

Results

AxSpA was reported by 472 participants (63% women) and disease activity (BASDAI4: 83%), ASASHI (≥moderately impaired: 91%) and work disability (absenteeism: 41%; presenteeism 82%) were high. Biological use was very low (20%), while 34% used opiates. Females had significantly higher BASDAI, ASAS HI, work absenteeism and presenteeism, although were less likely to receive biologics (26% versus 16%, P <0.01). Gender differences disappeared after correction for treatment.

Conclusions

This web survey in Latin American axSpA patients shows a high disease burden and work impairment. The use of biologics is low, while the use of opiates was alarmingly high. Women used significantly less biologics despite reporting a worse disease state and work disability, which could be due to treatment inequity.

The full text of this article is available in PDF format.

Keywords : Spondyloarthritis, Biologics, Gender, Burden, Chile


1  Both authors contributed equally to this work.


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