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Sous presse. Epreuves corrigées par l'auteur. Disponible en ligne depuis le mardi 17 mars 2020
Doi : 10.1016/j.therap.2020.02.020
Received : 21 September 2019 ;  accepted : 20 February 2020
Severe serotonin syndrome caused by an interaction between an antidepressant and a cough syrup

Pierre-Louis Declercq a, , Jean-Pierre Eraldi a, Marion Beuzelin a, Stéphanie Gélinotte a, Antoine Marchalot a, François Bougerol a, Delphine Allorge b, Marie-Anne Loriot c, d, Nicolas Paret c, d, Bruno Mégarbane e, f, Jean-Philippe Rigaud a
a Service de médecine intensive réanimation, hôpital de Dieppe, 76200 Dieppe, France 
b Unité fonctionnelle de toxicologie, centre hospitalo-universitaire de Lille, 59000 Lille, France 
c Université Paris Descartes, INSERM U1138, centre de recherches des Cordeliers, 75006 Paris, France 
d Service de biochimie, AP–HP, hôpital Européen-Georges-Pompidou, 75015 Paris, France 
e Réanimation médicale et toxicologique, hôpital Lariboisière, 75010 Paris, France 
f Université Paris-Diderot, INSERM UMRS-1144, 75013 Paris, France 

Corresponding author.

Keywords : Serotonin syndrome, Serotonergic properties, Drug interaction, Adverse reaction, Monoamine, Oxydase inhibitor, Dextromethorphan

 The case has been declared to the regional pharmacovigilance centre in Rouen (France) on 29/11/2017 under the number RN20172173.

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