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Joint Bone Spine
Sous presse. Epreuves corrigées par l'auteur. Disponible en ligne depuis le mardi 31 mars 2020
Doi : 10.1016/j.jbspin.2020.02.008
accepted : 26 February 2020
Ultrasonographic Involvement of the anterior chest wall in Spondyloarthritis: Factors associated with 5-years structural progression. A prospective study in 58 patients
 

Frank Verhoeven a, b, , Maxime Sondag a, Mickaël Chouk a, Clément Prati a, b, Daniel Wendling a, c
a Service de Rhumatologie, CHRU Besançon, France 
b EA 4267 PEPITE, FHU INCREASE, University Bourgogne Franche-Comté, 25030 Besançon, France 
c EA 4266 EPILAB, University Bourgogne Franche-Comté, 25030 Besançon, France 

Corresponding author at: Service de Rhumatologie, CHRU de Besançon, 3, boulevard Fléming, 25030 Besancon cedex, France.Service de Rhumatologie, CHRU de Besançon3, boulevard FlémingBesancon cedex25030France
Highlights

Ultrasonographic involvement of the anterior chest wall is frequent in Spondyloarthritis and is associated with disease activity.
New lesions of the anterior chest wall after 5 years of follow up are associated with high disease activity at 5 years.
Anterior chest wall could be a new target to evaluate structural outcome in Spondyloarthritis.

The full text of this article is available in PDF format.
Abstract
Introduction

To evaluate, factors associated with new ultrasonographic lesions of the anterior chest wall in spondyloarthritis (SpA) after a follow up of 5 years.

Methods

SpA Patients included in 2013 in a first study were evaluated five years later. Ultrasound B mode and power Doppler examination of the two sternoclavicular joints and the manubrio-sternal joint were performed by the same two examinators at baseline and five years later. The presence of erosion, synovitis, ankylosis, power Doppler signal, joint effusion and joint space narrowing were assessed blind of the first evaluation.

Results

Among the 131 patients at baseline, 58 patients were evaluated 5 years later. The mean age was 48.2±11.9 years old, with 86% of male and mainly an axial disease (78%). Patient characteristics are comparable to the original cohort. The most frequent lesions were ankylosis of the manubriosternal joint (38%) and erosions of the sternoclavicular joint (29%). 31 patients (53%) developed a new lesion of the ACW. There is a statistically significant association between new lesions of the ACW and higher ASDAS CRP (1,86±1,07 VS 3,0±2,17 P <0,01) and with CRP (5,34±7,85 VS 16,2±35, P =0,035) in the moment of the examination. There was no baseline factor associated with the structural progression.

Conclusion

The occurrence of new lesions of the anterior chest wall is associated with a higher disease activity and a higher CRP at 5 years.

The full text of this article is available in PDF format.

Keywords : Anterior chest wall, Structural progression, Ultrasonography, Disease activity




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