Access to the PDF text

Free Article !

Archives of cardiovascular diseases
Vol 101, N° 2  - février 2008
pp. 77-78
Doi : ACVD-02-2008-101-2-1875-2136-101019-200802433
REACH: from registry to harmonization
REACH : du registre jusqu’à l’harmonisation

J. Ferrières
[1] Service de cardiologie B, Centre hospitalier universitaire Rangueil, Toulouse.

Tirés à part : J. Ferrières

[2] Service de cardiologie B, Centre hospitalier universitaire Rangueil, TSA 50032, 31059 Toulouse cedex 9.

From 1980 to 2004, mortality due to cardiovascular disease has fallen by 52% in France [1]. This reduction is a major cause of satisfaction for the cardiological community. The improvement in prognosis is due to the management of cardiovascular disease and its risk factors. This large fall of cardiovascular mortality masks an important increase in the prevalence and costs generated by this chronic disease. Population registries are necessary to detect the best means of improving management of atherothombosis. Clinical trials will always provide the ultimate proof of the efficacy of a treatment in a selected sample. Nevertheless, the most recent clinical trials show that this remarkable management of cardiovascular disease does not necessarily reflect the real situation in the field.

The French REACH registry presented in this issue by Sabouret et al. [2] is an observational study. The one-year follow-up results for this cohort have been presented at international level [3] [4] [5] and are discussed for France in this article [2]. The REACH registry is not above criticism, as bias may be introduced during selection of the doctors taking part in the study and patients enrolled in this registry. This registry should consequently be considered to provide an optimistic view of the real situation. The outstanding finding of this study is the major cardiovascular event rate which increases from 11.7% at one year for a single atherothrombotic lesion to 22.3% at one year for several atherothrombotic localizations. It should be noted that the REACH registry includes patients with established atherothrombotic disease whereas a high prevalence of asymptomatic lesions is known to exist in patients presenting disease in a given territory [6], [7].

What lessons may be learned from the REACH study? The REACH study is first of all a superb example of the evaluation of professional practices. This evaluation may be made at a cross-sectional or longitudinal level. A cross-sectional approach is used to assess the appropriateness of prescriptions with recommendations whereas cohort studies evaluate the impact of management on cardiovascular events. The registry REACH data underline the need for a harmonization of practices in the treatment of a single disease, atherothombosis. Screening and management must be harmonized in the face of a common physiopathology. The community of doctors and researchers concerned by atherothombosis has not yet made any final recommendations about the harmonization of screening after the detection of a first cardiovascular event in a given territory. Should all atherothrombotic patients with peripheral arterial occlusive disease be screened by measuring the ankle-brachial pressure index [8]? Is it necessary to screen for carotid arterial disease in all patients after an acute coronary syndrome [9]? Should a test for ischemia or a coronary CT-scan be conducted in all patients with peripheral arterial occlusive disease or another atherothrombotic lesion [10], [11]? The data of many studies including the REACH registry seem to suggest that it is necessary to screen for disease in other territories once a first symptomatic localization is detected. From the point of view of therapy, the increasing harmonization of practices seems easier to achieve now that numerous studies have brought together cardiologists, neurologists and vascular specialists. This must not be restricted to university hospital collaboration and doctors working in the wider community must also benefit from these advances. Registries must therefore be multiplied as they provide an educational link between researchers and doctors practicing daily in the field of cardiovascular medicine. These registries make it possible to assess professional practices and measure the gap between the results of clinical trials and a real life setting. In all events, the REACH registry has achieved its main goal of making the cardiovascular community aware of the need for common global management of atherothrombotic disease.


Aouba A, Péquignot F, Le Toullec A, Jougla E. Les causes médicales de décès en France en 2004 et leur évolution 1980-2004. BEH 2007;35-36:308-14.
Sabouret P, Cacoub P, Dallongeville J et al. REACH: International prospective observational registry in patients at risk of atherothrombotic events. Results for the French arm at baseline and one year. Arch Card Dis 2008 (mettre le tome et la pagination)
Bhatt DL, Steg PG, Ohman EM, et al. International Prevalence, Recognition, and Treatment of Cardiovascular Risk Factors in Outpatients With Atherothrombosis. JAMA 2006;295:180-9.
Steg PG, Bhatt DL, Wilson PWF, et al. One-Year Cardiovascular Event Rates in Outpatients With Atherothrombosis. JAMA 2007;297:1197-206.
Touzé E, Mas JL, Röther J et al. Impact of carotid endarterectomy on medical secondary prevention after a stroke or a transient ischemic attack: results from the Reduction of Atherothrombosis for Continued Health (REACH) registry. Stroke 2006;37:2880-5
Ferrières J, Cambou JP, Gayet JL et al. Prognosis of patients with atherothrombotic disease: a prospective survey in a non-hospital setting. Int J Cardiol 2006;112:302-7.
Rothwell PM, Coull AJ, Silver LE, et al. Population-based study of event-rate, incidence, case fatality, and mortality for all acute vascular events in all arterial territories (Oxford Vascular Study). Lancet 2005;366:1773-83.
Beckman JA, Jaff MR, Creager MA. The United States preventive services task force recommendation statement on screening for peripheral arterial disease: more harm than benefit? Circulation 2006;114:861-6.
Lorenz MW, Markus HS, Bots ML, Rosvall M, Sitzer M. Prediction of clinical cardiovascular events with carotid intima-media thickness: a systematic review and meta-analysis. Circulation 2007; 115:459-67.
Kligfield P, Lauer MS. Exercise electrocardiogram testing: beyond the ST segment. Circulation 2006;114:2070-82.
Greenland P, Bonow RO, Brundage BH et al. American College of Cardiology Foundation Clinical Expert Consensus Task Force (ACCF/AHA Writing Committee to Update the 2000 Expert Consensus Document on Electron Beam Computed Tomography); Society of Atherosclerosis Imaging and Prevention; Society of Cardiovascular Computed Tomography. ACCF/AHA 2007 clinical expert consensus document on coronary artery calcium scoring by computed tomography in global cardiovascular risk assessment and in evaluation of patients with chest pain: a report of the American College of Cardiology Foundation Clinical Expert Consensus Task Force (ACCF/AHA Writing Committee to Update the 2000 Expert Consensus Document on Electron Beam Computed Tomography). Circulation. 2007; 115:402-26.

© 2008 Elsevier Masson SAS. Tous droits réservés.
EM-CONSULTE.COM is registrered at the CNIL, déclaration n° 1286925.
As per the Law relating to information storage and personal integrity, you have the right to oppose (art 26 of that law), access (art 34 of that law) and rectify (art 36 of that law) your personal data. You may thus request that your data, should it be inaccurate, incomplete, unclear, outdated, not be used or stored, be corrected, clarified, updated or deleted.
Personal information regarding our website's visitors, including their identity, is confidential.
The owners of this website hereby guarantee to respect the legal confidentiality conditions, applicable in France, and not to disclose this data to third parties.
Article Outline
You can move this window by clicking on the headline