Second-line drugs used in recent-onset rheumatoid arthritis in Brittany (France) - 01/01/02
Alain Saraux 1 * , Jean-Marie Berthelot 2 , Gérard Chalès 3 , Catherine Le Henaff 4 , Jean Thorel 5 , Sylvie Hoang 6 , Antoine Martin 7 , Jérôme Allain 1 , Isabelle Nouy-Trolle 8 , Valérie Devauchelle 1 , Pierre Youinou 1 , Paul Le Goff 1 *Correspondence and reprints: Service de Rhumatologie, Hôpital de la Cavale Blanche, BP 824, F 29609 Brest cedex, France
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Résumé |
Objective. The management of recent-onset rheumatoid arthritis (RA) is not well standardized. We conducted a survey of drugs prescribed to RA patients in Brittany at presentation and during the first 1 to 3 years of follow-up. Methods. A cohort of 270 patients with recent-onset inflammatory joint disease was recruited between 1995 and 1997. The evaluation at presentation included a medical history, a thorough physical examination, and a standard battery of investigations. Follow-up at 6-month intervals was offered. At the last visit, between June and December 1999, a panel of five rheumatologists established that 98 patients had RA. Results. At presentation, hydroxychloroquine and injectable gold were the most widely used second-line drugs, and only two patients were offered a combination of second-line drugs. At the last visit, the most commonly used drugs were methotrexate, injectable gold, and hydroxychloroquine (23, 23, and 21 patients, respectively); only three patients were on more than one second-line drug and 38 (38/98, 39%) patients were on glucocorticoid therapy. Conclusion. Rheumatologists in Brittany prefer monotherapy with hydroxychloroquine or injectable gold as the initial treatment. Later, they rely mainly on methotrexate, injectable gold, and hydroxychloroquine, often in combination with glucocorticoid therapy.
Mots clés : Brittany ; rheumatoid arthritis ; second-line drugs.
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Vol 69 - N° 1
P. 37-42 - janvier 2002 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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