Distribution of HLA-DRB1 genes in patients with sporadic ankylosing spondylitis in the south of Spain - 01/01/02
V.
Perez-Guijo
1
,
E.
Muñoz
2
,
A.
Escudero
1
,
R.
Veroz
1
,
M.
Sánchez
1
,
M.C.
Muñoz-Villanueva
1
,
R.
González
3
,
J.
Peña
3
,
E.
Collantes-Estevez
1
*
*Correspondence and reprints: Servicio de Reumatología, Hospital Universitario Reina Sofía (H Provincial), Avda. Menéndez Pidal s/n, 14004 Cordoba, Spain
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Résumé |
Objective. To evaluate the relationship between the presence of different HLA-DRB1 genes and predisposition to develop a sporadic form of ankylosing spondylitis (AS) in a demographically well-defined population. Methods. One hundred fifteen selected patients with sporadic (non-familial) forms of AS from six different cities and 748 bone marrow donors as control group. All individuals were typed for HLA-B27 by flow cytometry with monoclonal antibodies and PCR -SSP, as well as for HLA-DRB using the Dynal ELI SSO HLA-DRB Test (Dynal AS, Oslo, Norway). The Inno-Lipa DRB Decoder (Innogenetics NV Zwijndrecht, Belgium), was used for high-resolution HLA -DRB typing. Results. The presence of the DRB1*01 antigen in the studied population is significantly higher in B27 positive healthy individuals (bone marrow donors) than in B27 positive AS patients; also, DRB1*01 is higher in B27 negative AS patients than B27 negative controls. The frequency of DRB1*03 is higher in B27 negative controls than B27 negative AS patients. Conclusion. The results of this study suggest that DRB1*01 antigens might be involved in the development of sporadic forms of ankylosing spondylitis in HLA-B27 negative individuals in the studied area.
Mots clés : class II MHC ; HLA-B27 ; HLA-DR ; sporadic ankylosing spondylitis.
Plan
Vol 69 - N° 5
P. 458-462 - octobre 2002 Retour au numéro
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