Treatment preference for monthly oral ibandronate and weekly oral alendronate in women with postmenopausal osteoporosis: A randomized, crossover study (BALTO II) - 06/05/08
, Helmut Minne b, Michael Pfeifer b, Pierre Bourgeois c, Patrice Fardellone d, Angelo Licata e, Vipul Devas f, Daiva Masanauskaite g, Elizabeth Barrett-Connor h
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Abstract |
Objectives |
Patient preference strongly influences long-term medication use in chronic diseases such as postmenopausal osteoporosis.
Methods |
This 6-month, open-label, crossover, international study randomized 350 women with postmenopausal osteoporosis to monthly oral ibandronate 150mg for 3months followed by weekly alendronate 70mg for 12weeks, or vice versa.
Results |
Of patients expressing a preference (93.1%), more preferred the monthly ibandronate regimen (70.6%) than the weekly alendronate regimen (29.4%). The monthly ibandronate preference rate was statistically significant (P<0.0001). The most common reasons for ibandronate preference were ease of staying on treatment long-term (81.5%) and better lifestyle fit (75.4%). More women found the monthly ibandronate regimen more convenient (76.6%) than the weekly alendronate regimen (23.4%). The monthly ibandronate convenience rate was statistically significant (P<0.0001). The safety profiles of the two regimens were similar.
Conclusion |
The strong patient preference for monthly ibandronate over weekly alendronate replicates previous study findings and may lead to improved treatment adherence in women with postmenopausal osteoporosis.
Le texte complet de cet article est disponible en PDF.Keywords : Ibandronate, Alendronate, Monthly, Preference, Postmenopausal osteoporosis
Plan
Vol 75 - N° 3
P. 303-310 - mai 2008 Retour au numéro
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