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Archives de pédiatrie
Volume 8, n° S4
pages 752-756 (septembre 2001)
Doi : S0929-693X(01)80192-5
Infections graves à pneumocoques : facteurs de pathogénicité
Virulence of S. pneumoniae

E. Varon
Centre national de référence des pneumocoques, hôpital Européen Georges Pompidou, 20-40, rue Leblanc, 75908 Paris cedex 15, France 


Pendant longtemps, la virulence du pneumocoque a été attribuée à sa capsule, qui s'oppose à la phagocytose. En fait S. pneumoniae synthétise différents facteurs impliqués dans la virulence. Ceux-ci comprennent une toxine puissante, la pneumolysine, capable de lyser n'importe quelle cellule eucaryote, et toute une série de protéines de surface liant la choline : la protéine majoritaire CbpA et PsaA jouent le rôle d'adhésines, l'autolysine LytA libère les acides teichoïques et lipoteichoïques de la paroi, puissants médiateurs de l'inflammation ; le rôle de PspA n'est pas complètement élucidé. Ensemble, ces facteurs contribuent à la colonisation, l'inhibition de la phagocytose, l'invasion, l'inflammation et la destruction des tissus.

The full text of this article is available in PDF format.

For many years, the virulence of S. pneumoniae has largely been attributed to its anti-phagocytic capsule. However S. pneumoniae elaborate other various factors that contribute to virulence. These include the toxin pneumolysin, lytic for all eukaryotic cells, and a variety of choline-binding surface proteins ; the most abundant CbpA and PsaA function as cell surface adhesins, the autolysin LytA is responsible for release of lipoteichoic and techoic acids which are mediators of host inflammatory response, the role of PspA remains to be demonstrated. These factors contribute together to the colonization, protection from phagocytosis, invasion, inflammatory response, and tissue damage.

The full text of this article is available in PDF format.

Mots-clé : Streptococcus pneumoniae / virulence / capsule / pneumolysine / protéines de surface / choline

Keywords : Streptococcus pneumoniae / virulence / capsule / pneumolysin / surface proteins / choline

© 2001  Published by Elsevier Masson SAS.
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