Interleukin-1 receptor antagonist gene polymorphisms are associated with disease severity in Black South Africans with rheumatoid arthritis - 11/07/08
, Lize van der Merwe d, Bridget Hodkinson b, c, Michele Ramsay a, b
Corresponding author. Division of Rheumatology, Department of Medicine, Chris Hani Baragwanath Hospital, Old Potch Road, Diepkloof, Soweto, P.O. Bertsham, 2013, Johannesburg, South Africa. Tel.: +27 11 933 9377; fax: +27 11 938 8738.Bienvenue sur EM-consulte, la référence des professionnels de santé.
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Abstract |
Objective |
To test for genetic associations between polymorphisms of the interleukin-1 (IL-1) gene cluster and disease susceptibility and severity in Black South Africans with rheumatoid arthritis (RA).
Methods |
Allele and genotype frequencies of IL1B (−511) and (+3954) and IL1RN variable number of tandem repeat (VNTR) and (+2018) were compared between 141 RA patients and 101 healthy controls.
Results |
No significant differences in allelic distribution at the four loci were observed between RA patients and controls. Within the RA group, the IL1RN*2 (two repeats of an 86bp tandem repeat) at the IL1RN VNTR locus was independently associated with higher Larsen radiologic damage scores (LDS), corrected for disease duration (p=0.04). Moreover, the inferred haplotype, consisting of IL1RN*2 and (+2018) ‘C’ allele, was associated with significantly higher LDS, on average 15 points higher, compared to the base haplotype of IL1RN*long (three or more repeats) and (+2018) ‘T’ allele (p=0.009). The common IL1B (−511) ‘T’ allele was associated with a poorer modified health assessment questionnaire disability index (p=0.02).
Conclusion |
Our findings provide further evidence of a possible role of polymorphisms of the IL-1 gene cluster in disease severity in RA, and particularly IL1RN*2 as a marker of erosive joint damage in Black South Africans with RA.
Le texte complet de cet article est disponible en PDF.Keywords : Rheumatoid arthritis, Interleukin-1, Genetics, Blacks, Africa
Plan
Vol 75 - N° 4
P. 422-425 - juillet 2008 Retour au numéro
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