Budget impact model of rituximab after failure of one or more TNF inhibitor therapies in the treatment of rheumatoid arthritis - 06/01/09
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Abstract |
Objectives |
To estimate the budget impact implied by the introduction of rituximab after failure of one or more anti-TNF⍺ therapies in the perspective of the French health care system.
Methods |
A Markov model reproduced the course, over 4years, of patients treated either by infliximab, etanercept, adalimumab or RTX, after failure of one or more anti-TNF⍺ therapies, in a multicentric study. A sensitivity analysis was developed to account for patients in 3rd and subsequent lines of treatment who are expected to consume more healthcare resources.
Results |
When RTX is not used, total annual medical cost is €16,555 per patient, €13,206 of which are dedicated to drug acquisition. When RTX is the only treatment in use, these costs decrease respectively to €11,444 and €7469. Total savings per patient and per year is €5000. Over 4years, total savings for the targeted population reach €118M. In the sensitivity analysis, the difference between H2 and H2-coeff 2 (20%) reaches €5,400,000 in total direct costs during the first year of simulation. This difference decreases along the period, to reach €2,400,000 the fourth year of simulation, and is due to the fact that rituximab acquisition costs are independent from the treatment line.
Conclusion |
If TNF⍺ inhibitors were the only treatment available, the annual global cost of treatment would be €16,555 per patient versus €11,444 for patients treated exclusively with rituximab. RTX is expected to produce important savings (−31%) if used after failure of one or more TNF⍺ therapies. This is mainly due to its lower drug acquisition cost. These savings could increase with the development of rituximab in earlier stages of treatment.
Le texte complet de cet article est disponible en PDF.Keywords : Rheumatoid arthritis, Costs, Rituximab, TNF⍺ inhibitors, Budget impact
Plan
Vol 75 - N° 6
P. 688-695 - décembre 2008 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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