Lovastatin inhibits adipogenesis and prevents osteonecrosis in steroid-treated rabbits - 06/01/09
, Pei Fuxing b, Shen Bin b, Yang Jing b, Cheng Jingqiu b
Corresponding author.Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
| pages | 6 |
| Iconographies | 3 |
| Vidéos | 0 |
| Autres | 0 |
Abstract |
Objectives |
To investigate in vivo effects of lovastatin on inhibition of adipogenesis, an important mechanism of steroid-induced osteonecrosis, and on prevention of occurrence of steroid-induced osteonecrosis in rabbits.
Methods |
Fifty-four rabbits were intramuscularly injected once with 20mg/kg of methylprednisolone acetate (MPSL). Then, they were divided into two groups: lovastatin was given in Group I and placebo was given in Group II. And another 16 rabbits were injected with physiologic saline (PS) as a control (Group III). Hematological examination was performed for serum lipid levels. Both the femora and the humeri were histopathologically examined for the presence of osteonecrosis before the injection and 1, 2, 4 and 12 weeks after the injection.
Results |
The serum lipid levels were significantly higher in Group II than in Groups I and III 1, 2 and 4 weeks after the injection. The incidence of osteonecrosis was significantly higher in Group II (69%) than in Group I (36%) and Group III (0%). Pathological examination showed less serious adipogenesis and bone death in Group I than in Group II. The size and area of the fat cells in the bone marrow were significantly smaller in Group I (47.5±1.3μm, 25%) and Group III (41.7±1.6μm, 12%) than in Group II (59.8±6.3μm, 51%) (P< 0.001).
Conclusion |
Lovastatin can prevent development of steroid-induced osteonecrosis in rabbits by inhibiting adipogenesis. Future evaluation on the effectiveness of lovastatin in the clinical practice is still necessary.
Le texte complet de cet article est disponible en PDF.Keywords : Adipogenesis, Corticosteroid, Lovastatin, Marrow fat cell, Osteonecrosis, Rabbit
Plan
Vol 75 - N° 6
P. 696-701 - décembre 2008 Retour au numéro
Article précédent
- Budget impact model of rituximab after failure of one or more TNF
inhibitor therapies in the treatment of rheumatoid arthritis - Robert Launois, Stéphanie Payet, Nathalie Saidenberg-Kermanac'h, Camille Francesconi, Lionel Riou França, Marie-Christophe Boissier
- Prevalence of risk factors for referring post-menopausal women for bone densitometry. The INSTANT study
- Christian Roux, Patrice Fardellone, Eric Lespessailles, François-Emery Cotté, Florence Mercier, Anne-Françoise Gaudin
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’achat d’article à l’unité est indisponible à l’heure actuelle.
Déjà abonné à cette revue ?