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Archives of cardiovascular diseases
Volume 102, n° S1
page 17 (mars 2009)
Doi : 10.1016/S1875-2136(09)72162-X
Themes et posters

A029 Identification of polymorphisms in the gene encoding secreted phospholipase A2 group X and study of their role in coronary artery disease. The atherogene study
 

S. Gora 1, C. Perret 1, I. Jemel 2, V. Nicaud 1, G. Lambeau 2, F. Cambien 1, E. Ninio 1, S. Blankenberg 3, L. Tiret 1, S.-A. Karabina 1
1 Inserm UMRS937, Paris, France 
2 IPMC ; CNRS UMR 6097, Sophia-Antipolis, France 
3 Johannes Gutenberg-University, Mainz, Germany 

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Human secreted phospholipases A2 (sPLA2s) represent novel attractive therapeutic targets and biomarkers in coronary artery diseases (CAD). We have shown that human Group X sPLA2 (hGX sPLA2) is present in atherosclerotic lesions and that hGX sPLA2 modified LDL induces foam cell formation. To elucidate whether hGX sPLA2 has a causative role in CAD we have screened the human PLA2G10 gene to identify frequent polymorphisms, and we have examined their possible association with cardiovascular end-points and intermediate inflammatory phenotypes in a large prospective study of patients with CAD (the AtheroGene study). Although no significant association was found between the various polymorphisms identified and lipids or inflammatory markers, patients carriers of the C allele of the T-512C polymorphism located in the 5’ untranslated region showed a decreased risk of recurrent cardiovascular events. Molecular analysis of the only missense variant (R38C) showed its functional relevance as it leads to a profound change in expression and secretion of hGX sPLA2.

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