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Archives de pédiatrie
Volume 16, n° 7
pages 1085-1089 (juillet 2009)
Doi : 10.1016/j.arcped.2009.03.008
Les biphosphonates dans l’ostéogenèse imparfaite
Biphosphonates and osteogenesis imperfecta in children
 

S. Gandon-Laloum
Service de chirurgie infantile, centre hospitalier régional universitaire de Caen, avenue de la Côte-de-Nacre, 14033 Caen cedex 9, France 

Résumé

Utilisés depuis une dizaine d’années en complément de la physiothérapie, de la chirurgie orthopédique et de la rééducation, les biphosphonates ont transformé la prise en charge des enfants atteints d’une forme grave ou moyenne d’ostéogenèse imparfaite. Les auteurs de cet article préciseront ici les indications, les modes d’administration, la durée du traitement, les effets secondaires potentiels, en rappelant les incertitudes liées à leur persistance dans le tissu osseux pendant de longues années.

The full text of this article is available in PDF format.
Abstract

Used for more than 10 years in addition to physiotherapy, orthopaedic surgery and rehabilitation, biphosphonate therapy has transformed the management of children with severe or moderate form of osteogenesis imperfecta. The authors of this article report indications, administration’s way, duration and safety of biphosphonate therapy with uncertainties about persistence in skeleton for many years.

The full text of this article is available in PDF format.

Mots clés : Biphosphonates, Ostéogenèse imparfaite, Enfant




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