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Annales de Dermatologie et de Vénéréologie
Volume 136, n° S4
pages 129-136 (mai 2009)
Doi : 10.1016/S0151-9638(09)74540-5
La toxine botulique dans les maladies dermatologiques invalidantes
Botulinum toxin in disabling dermatological diseases
 

R. Messikh, L. Atallah, F. Aubin, P. Humbert
Service de Dermatologie, CHU Saint-Jacques, Université de Franche-Comté, INSERM U645, 25030 Besançon cedex 

Auteur correspondant.
Résumé

La toxine botulique représente aujourd’hui une nouvelle modalité thérapeutique d’un certain nombre d’infections pour lesquelles les traitements conventionnels sont inopérants. Au côté de l’hyperhidrose palmo-plantaire, la toxine botulique s’est avérée efficace dans plusieurs maladies s’accompagnant d’une hyperhidrose, telles que la dyshidrose, les hidrocystomes eccrines multiples, l’hidradénite suppurative, le syndrome de Frey, ou dans des pathologies aggravées par l’hyperhidrose, comme la maladie de Hailey-Hailey, la maladie de Darier, le psoriasis inversé, la kératodermie palmo-plantaire aquagénique, la pachyonychie congénitale. De plus, un certain nombre de maladies s’accompagnant de troubles sensitifs cutanés et/ou d’une atteinte neurologique bénéficient efficacement de la toxine botulique, par exemple les fissures anales, les ulcères de jambe, le lichen simplex, la notalgia paresthetica , la vestibulite. De façon plus anecdotique, un cas de cutis laxa a pu bénéficier de ce traitement.

The full text of this article is available in PDF format.
Summary

Botulinum toxin could represent nowadays a new treatment modality especially for cutaneous conditions in course of which conventional treatments remain unsuccessfull. Besides palmar and plantar hyperhidrosis, botulinum toxin has demonstrated efficacy in different conditions associated with hyperhidrosis, such as dyshidrosis, multiple eccrine hidrocystomas, hidradenitis suppurativa, Frey syndrome, but also in different conditions worsened by hyperhidrosis such as Hailey-Hailey disease, Darier disease, inversed psoriasis, aquagenic palmoplantar keratoderma, pachyonychia congenital. Moreover, different cutaneous conditions associated with sensitive disorders and/or neurological involvements could benefit from botulinum toxin, for example anal fissures, leg ulcers, lichen simplex, notalgia paresthetica , vestibulitis. Endly, a case of cutis laxa was described where the patient was improved by cutaneous injections of botulinum toxin.

The full text of this article is available in PDF format.

Mots clés : Toxine botulique, Dyshidrose, Vestibulite, Maladie de Darier, Notalgia paresthetica

Keywords : Botulinum toxin, Dyshidrosis, Vestibulitis, Darier disease, Notalgia paresthetica




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