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Annales de Dermatologie et de Vénéréologie
Volume 136, n° S4
pages 86-88 (mai 2009)
Doi : 10.1016/S0151-9638(09)74533-8
Les effets à long terme de la toxine botulique
Long-term effects of botulinum toxin treatment

P. Krystkowiak
Service de neurologie, CNRS UMR 8160, CHU d’Amiens, 80054 Amiens cedex 


La toxine botulique (BoNT) est utilisée à des fins médicales depuis un quart de siècle. Son excellent profil efficacité/effets indésirables se maintient sur le long terme, comme en attestent toutes les études cliniques concernant diverses indications, la plupart dans le domaine de la neurologie. Qui plus est, les effets indésirables sont, dans la grande majorité des cas, locaux et spontanément réversibles. L’allo-immunisation à la BoNT, par le biais du développement d’anticorps neutralisants, n’entraîne aucune conséquence significative en pratique quotidienne.

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Long-term BoNT treatment administration has been assessed in various treatment settings (especially in neurology), with the level and duration of BoNT efficacy response being maintained with no major safety problems. Most side effects are local one and are transient. The incidence of antibody development is low and does not induce significant concerns in clinical practice.

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Mots clés : Traitement à long terme, Toxine botulique, Sérotype A, Anticorps neutralisants

Keywords : Long-term treatment, Botulinum toxin, Serotype A, Neutralizing antibodies

© 2009  Elsevier Masson SAS. All Rights Reserved.
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